Design, synthesis, and biological evaluation of chalcones for anticancer properties targeting glycogen synthase kinase 3 beta

• Published in: Applied biological chemistry Vol. 65; no. 1; p. 17
• Main Authors: Ahn, Seunghyun, Truong, Vi Nguyen-Phuong, Kim, Beomsoo, Yoo, Miri, Lim, Yoongho, Cho, Somi Kim, Koh, Dongsoo
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.12.2022; Springer Nature B.V; 한국응용생명화학회
• Subjects: Anticancer properties; antineoplastic activity; Antitumor activity; Apoptosis; Applied Microbiology; Assaying; Binding; biological assessment; Biological Techniques; Bioorganic Chemistry; Cancer; Cell viability; chalcone; Chemistry; Chemistry and Materials Science; computer simulation; dose response; Drug development; Glycogen; Glycogen synthase kinase 3; Glycogens; Kinases; Mass spectrometry; Mass spectroscopy; Mesenchyme; NMR; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Survival; tau-protein kinase; Western blotting; Wound healing; 농학; GSK3β; In silico docking; Colonogenic; Chalcone; MCF-7SC

Chalcones compounds have been investigated to exhibit anticancer activity through various physiological modes of action. In order to develop chalcone compounds with novel anticancer-related modes of action, diverse chalcone compounds were designed and synthesized. Variously substituted poly-methoxy...