Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells

• Published in: Nature communications Vol. 13; no. 1; p. 2018
• Main Authors: Lohraseb, Iman, McCarthy, Peter, Secker, Genevieve, Marchant, Ceilidh, Wu, Jianmin, Ali, Naveid, Kumar, Sharad, Daly, Roger J, Harvey, Natasha L, Kawabe, Hiroshi, Kleifeld, Oded, Wiszniak, Sophie, Schwarz, Quenten
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 19.04.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Actin; Actins - metabolism; Biology; Cancer; Cell survival; Cytoskeleton; Endosomal Sorting Complexes Required for Transport - metabolism; Gene expression; Lysine; Medical research; Morphology; Nedd4 Ubiquitin Protein Ligases - genetics; Nedd4 Ubiquitin Protein Ligases - metabolism; Nervous system; Neural crest; Neural Crest - metabolism; Neurosciences; Peptides; Peripheral nervous system; Polymerization; Profilin; Profilins - genetics; Profilins - metabolism; Proteins; Proteomes; Proteomics; Roles; Signal transduction; Stem cells; Systems development; Transcription factors; Transcriptomes; Ubiquitin; Ubiquitin - metabolism; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination

The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial and peripheral nervous system development. However, how ubiquitination and NEDD4 control NCC development remains unknown. Here we combine quantitative analysis of the proteome,...