Short-term particulate matter exposure induces extracellular vesicle release in overweight subjects

• Published in: Environmental research Vol. 155; pp. 228 - 234
• Main Authors: Bonzini, Matteo, Pergoli, Laura, Cantone, Laura, Hoxha, Mirjam, Spinazzè, Andrea, Del Buono, Luca, Favero, Chiara, Carugno, Michele, Angelici, Laura, Broggi, Lucia, Cattaneo, Andrea, Pesatori, Angela C., Bollati, Valentina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2017; Elsevier
• Subjects: Adult; Aged; Air Pollutants - analysis; Air pollution susceptibility; body mass index; breathing; confidence interval; Environmental Monitoring; exposure assessment; Extracellular Vesicles; Female; Flow cytometry; geometry; Humans; Male; Microvesicles; Middle Aged; monitoring; Overweight; Overweight - blood; Particulate Matter - analysis; particulates; PM exposure; regression analysis; Flow cytometry; CI; Air pollution susceptibility; MV; EV-miRNA; CFSE; IQR; Microvesicles; GMR; Overweight; CVD; EV; PCIS; NTA; PM exposure; ARPA; PM; BMI

Extracellular vesicles (EVs) represent a plausible molecular mechanism linking particulate matter (PM) inhalation to its systemic effects. Microvesicles (MVs) are released from many cell types in response to various stimuli. Increased body mass index (BMI) could modify the response to PM exposure du...