Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension

• Published in: Physiological reviews Vol. 99; no. 1; pp. 235 - 309
• Main Authors: Gonzalez-Vicente, Agustin, Saez, Fara, Monzon, Casandra M, Asirwatham, Jessica, Garvin, Jeffrey L
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2019
• Subjects: Animal models; Animals; Autocrine signalling; Blood pressure; Blood Pressure - physiology; Diuretics; Electrolyte balance; Extremities - blood supply; Humans; Hypertension; Hypertension - metabolism; Ion Transport - physiology; Kidneys; Limbs; Paracrine signalling; Physiology; Review; Sodium; Sodium - metabolism; Water-Electrolyte Balance - physiology

The thick ascending limb plays a key role in maintaining water and electrolyte balance. The importance of this segment in regulating blood pressure is evidenced by the effect of loop diuretics or local genetic defects on this parameter. Hormones and factors produced by thick ascending limbs have bot...