Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 316; no. 1; pp. L216 - L228
• Main Authors: Wang, Ziyi, Yang, Kai, Zheng, Qiuyu, Zhang, Chenting, Tang, Haiyang, Babicheva, Aleksandra, Jiang, Qian, Li, Meichan, Chen, Yuqin, Carr, Shane G., Wu, Kang, Zhang, Qian, Balistrieri, Angela, Wang, Christina, Song, Shanshan, Ayon, Ramon J., Desai, Ankit A., Black, Stephen M., Garcia, Joe G. N., Makino, Ayako, Yuan, Jason X.-J., Lu, Wenju, Wang, Jian
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2019
• Subjects: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors - metabolism; Bcl-2 protein; bcl-2-Associated X Protein - metabolism; Calcium (reticular); Calcium - metabolism; Calcium channels; Calcium influx; Calcium ions; Cell cycle; Cell Proliferation; Cells; Crosstalk; Depletion; Endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; Gene expression; Hypertension; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - pathology; Hypoxia; Hypoxia - complications; Hypoxia - metabolism; Hypoxia - pathology; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factors; Lung diseases; Male; Mice; Monocrotaline; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Muscles; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; p53 Protein; Proteins; Proto-Oncogene Proteins c-bcl-2 - metabolism; Pulmonary arteries; Pulmonary Artery - metabolism; Pulmonary Artery - pathology; Pulmonary hypertension; Sarcoplasmic reticulum; Sarcoplasmic Reticulum - metabolism; Sarcoplasmic Reticulum - pathology; Senescence; Smooth muscle; Transient receptor potential proteins; Tumor Suppressor Protein p53 - metabolism; Vascular diseases; smooth muscle cell proliferation; Bcl-2 proteins; tumor-suppressor gene; endothelial cell apoptosis; p53

The tumor-suppressive role of p53, a transcription factor that regulates the expression of many genes, has been linked to cell cycle arrest, apoptosis, and senescence. The noncanonical function or the pathogenic role of p53 has more recently been implicated in pulmonary vascular disease. We previous...