Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology

• Published in: Biochimica et biophysica acta Vol. 1851; no. 6; pp. 724 - 735
• Main Authors: Grabon, Aby, Khan, Danish, Bankaitis, Vytas A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2015
• Subjects: Biological Transport; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase - genetics; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase - metabolism; enzymes; eukaryotic cells; Gene Expression Regulation; Humans; inositol phosphates; Lipid Metabolism; lipids; Models, Molecular; Phosphatidylinositol transfer proteins; Phosphatidylinositols - metabolism; Phospholipid Transfer Proteins - genetics; Phospholipid Transfer Proteins - metabolism; Phosphotransferases (Alcohol Group Acceptor) - genetics; Phosphotransferases (Alcohol Group Acceptor) - metabolism; physiology; proteins; Regulation of lipid kinases; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Signal Transduction; Signaling diversity; Type C Phospholipases - genetics; Type C Phospholipases - metabolism; Signaling diversity; Phosphatidylinositol transfer proteins; Regulation of lipid kinases

Phosphatidylinositol is a metabolic precursor of phosphoinositides and soluble inositol phosphates. Both sets of molecules represent versatile intracellular chemical signals in eukaryotes. While much effort has been invested in understanding the enzymes that produce and consume these molecules, cent...