Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

• Published in: American journal of respiratory and critical care medicine Vol. 203; no. 11; pp. 1419 - 1430
• Main Authors: Li, Wei, Long, Lu, Yang, Xudong, Tong, Zhen, Southwood, Mark, King, Ross, Caruso, Paola, Upton, Paul D, Yang, Peiran, Bocobo, Geoffrey A, Nikolic, Ivana, Higuera, Angelica, Salmon, Richard M, Jiang, He, Lodge, Katharine M, Hoenderdos, Kim, Baron, Rebecca M, Yu, Paul B, Condliffe, Alison M, Summers, Charlotte, Nourshargh, Sussan, Chilvers, Edwin R, Morrell, Nicholas W
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.06.2021
• Subjects: Acute Lung Injury - blood; Acute Lung Injury - etiology; Acute Lung Injury - pathology; Animals; Case-Control Studies; Chronic obstructive pulmonary disease; Endothelial Cells - metabolism; Endothelium - pathology; Endotoxemia - blood; Endotoxemia - etiology; Endotoxemia - pathology; Female; Growth Differentiation Factor 2 - blood; Humans; Lung diseases; Male; Mice; Original; Pulmonary Edema - blood; Pulmonary Edema - etiology; Pulmonary Edema - pathology; Pulmonary hypertension; Respiratory diseases; Respiratory distress syndrome; Sepsis - blood; Sepsis - etiology; Sepsis - pathology; BMP signaling in endothelial cells; BMP9; lung injury; pulmonary endothelium

Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating BMP9 (bone morphogenetic protein 9) is emerging as an important regulator of pulmonary vascular homeostasis. To determine whether endogenous BMP...