Lymphotoxin-β Receptor Signaling through NF-κB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells

• Published in: Immunity (Cambridge, Mass.) Vol. 37; no. 4; pp. 721 - 734
• Main Authors: Bénézech, Cécile, Mader, Emma, Desanti, Guillaume, Khan, Mahmood, Nakamura, Kyoko, White, Andrea, Ware, Carl F., Anderson, Graham, Caamaño, Jorge H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.10.2012
• Subjects: Adipocytes - cytology; Adipocytes - immunology; Animals; Cell Differentiation; Cell Movement; Cells, Cultured; Lymph Nodes - immunology; Lymphotoxin beta Receptor - immunology; Mice; NF-kappa B p52 Subunit - immunology; NF-kappa B p52 Subunit - metabolism; Phenotype; Signal Transduction; Stromal Cells - immunology; Transcription Factor RelB - immunology; Transcription Factor RelB - metabolism

Lymph node development during embryogenesis involves lymphotoxin-β receptor engagement and subsequent differentiation of a poorly defined population of mesenchymal cells into lymphoid tissue organizer cells. Here, we showed that embryonic mesenchymal cells with characteristics of adipocyte precursor...