Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity

• Published in: Applied physiology, nutrition, and metabolism Vol. 45; no. 7; pp. 715 - 722
• Main Authors: Inoue, Kenichiro, Fujie, Shumpei, Hasegawa, Natsuki, Horii, Naoki, Uchida, Masataka, Iemitsu, Keiko, Sanada, Kiyoshi, Hamaoka, Takafumi, Iemitsu, Motoyuki
• Format: Journal Article
• Language: English
• Published: 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7 NRC Research Press 01.07.2020; Canadian Science Publishing NRC Research Press
• Subjects: Adult; adults; aerobic exercise training; Aerobics; AMP-activated protein kinase; Animals; arterial stiffness; blood serum; correlation; Diagnostic reagents industry; Disease Models, Animal; endothelial nitric oxide synthase; Endothelium; entraînement à l’exercice aérobie; Exercise; Exercise - physiology; fibronectin type III domain containing 5; fibronectine du domaine de type III contenant 5 protéines; Fibronectins; Fibronectins - biosynthesis; Fibronectins - genetics; Fitness training programs; Gene expression; Humans; irisin; irisine; Kinases; Male; metabolism; muscles; nitrates; Nitric oxide; Nitric Oxide - metabolism; nitrites; non-specific serine/threonine protein kinase; nutrition; Obesity; Obesity - physiopathology; obésité; oxyde nitrique; oxyde nitrique synthase endothéliale; peak oxygen uptake; Phosphorylation; Physical fitness; Protein kinases; Rats; Rats, Inbred OLETF; rigidité artérielle; RNA; Rodents; secretion; signal transduction; Training; Vascular Stiffness - physiology; velocity; United Kingdom; Japan; arterial stiffness; nitric oxide; oxyde nitrique; entraînement à l’exercice aérobie; oxyde nitrique synthase endothéliale; fibronectine du domaine de type III contenant 5 protéines; obésité; endothelial nitric oxide synthase; irisine; aerobic exercise training; fibronectin type III domain containing 5; irisin; obesity; rigidité artérielle

This study aimed to clarify whether muscle-derived irisin secretion induced by aerobic exercise training is involved in reduction of arterial stiffness via arterial nitric oxide (NO) productivity in obesity. In animal study, 16 Otsuka Long-Evans Tokushima Fatty (OLETF) rats with obesity were randoml...