Patent Foramen Ovale Closure Decreases the Incidence but Not the Size of New Brain Infarction on Magnetic Resonance Imaging: An Analysis of the REDUCE Trial

• Published in: Stroke (1970) Vol. 52; no. 11; pp. 3419 - 3426
• Main Authors: Messé, Steven R, Erus, Guray, Bilello, Michel, Davatzikos, Christos, Andersen, Grethe, Iversen, Helle K, Roine, Risto O, Sjöstrand, Christina, Rhodes, John F, Søndergaard, Lars, Kasner, Scott E
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.11.2021
• Subjects: Brain Infarction - epidemiology; Brain Infarction - etiology; Brain Infarction - pathology; Clinical Trials; Foramen Ovale, Patent - complications; Foramen Ovale, Patent - surgery; Humans; Incidence; Magnetic Resonance Imaging; Medicin och hälsovetenskap

Randomized patent foramen ovale closure trials have used open-label end point ascertainment which increases the risk of bias and undermines confidence in the conclusions. The Gore REDUCE trial prospectively performed baseline and follow-up magnetic resonance imaging (MRIs) for all subjects providing...