The structural basis for insulin-like growth factor I receptor high affinity binding

• Published in: The Journal of biological chemistry Vol. 263; no. 31; pp. 16267 - 16273
• Main Authors: Tollefsen, S E, Thompson, K
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 05.11.1988; American Society for Biochemistry and Molecular Biology
• Subjects: Binding, Competitive; Biological and medical sciences; Cell Membrane - metabolism; Cell physiology; Dithiothreitol - pharmacology; Female; Fundamental and applied biological sciences. Psychology; Hormonal regulation; Humans; IGF-I; Insulin-Like Growth Factor I - metabolism; Insulin-Like Growth Factor I - pharmacology; Kinetics; Macromolecular Substances; Molecular and cellular biology; Molecular Weight; Phosphorylation; Placenta - metabolism; Pregnancy; Receptor, Insulin - drug effects; Receptor, Insulin - isolation & purification; Receptor, Insulin - metabolism; Receptors, Somatomedin; Somatomedins - metabolism; Human; Affinity; Molecular interaction; Membrane receptor; Somatomedin C

We have recently identified high and low affinity insulin-like growth factor I (IGF I) binding sites in solubilized human placental membranes and purified the high affinity IGF I receptor by IGF I affinity chromatography (Tollefsen, S. E., Thompson, K., and Petersen, D. J. (1987) J. Biol. Chem. 262,...