The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 55; no. 4; p. 466
• Main Authors: Gordon, Rachel J, Chez, Nancy, Jia, Haomiao, Zeller, Barbara, Sobieszczyk, Magda, Brennan, Caitlin, Hisert, Katherine B, Lee, Mei-Ho, Vavagiakis, Peter, Lowy, Franklin D
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Administration, Intranasal; Adult; AIDS-Related Opportunistic Infections - drug therapy; Anti-Bacterial Agents - administration & dosage; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methicillin Resistance; Mupirocin - administration & dosage; Ointments; Staphylococcal Skin Infections - drug therapy; Staphylococcus aureus - drug effects; Treatment Outcome

HIV-positive patients at HELP/PSI, Inc, an in-patient drug rehabilitation center, had a high baseline prevalence of Staphylococcus aureus colonization (49%) and incidence of infection (17%) in a previous year-long study. A randomized, double-blinded, placebo-controlled study was conducted to determi...