A platform for oncogenomic reporting and interpretation

• Published in: Nature communications Vol. 13; no. 1; p. 756
• Main Authors: Reisle, Caralyn, Williamson, Laura M, Pleasance, Erin, Davies, Anna, Pellegrini, Brayden, Bleile, Dustin W, Mungall, Karen L, Chuah, Eric, Jones, Martin R, Ma, Yussanne, Lewis, Eleanor, Beckie, Isaac, Pham, David, Matiello Pletz, Raphael, Muhammadzadeh, Amir, Pierce, Brandon M, Li, Jacky, Stevenson, Ross, Wong, Hansen, Bailey, Lance, Reisle, Abbey, Douglas, Matthew, Bonakdar, Melika, Nelson, Jessica M T, Grisdale, Cameron J, Krzywinski, Martin, Fisic, Ana, Mitchell, Teresa, Renouf, Daniel J, Yip, Stephen, Laskin, Janessa, Marra, Marco A, Jones, Steven J M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 09.02.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Biomarkers, Tumor; Cancer; Carcinogenesis - genetics; Complexity; Databases, Genetic; Genetic Variation; Genomics; Humans; Knowledge Bases; Knowledge bases (artificial intelligence); Neoplasms - genetics; Oncology; Precision Medicine; Tumors

Manual interpretation of variants remains rate limiting in precision oncology. The increasing scale and complexity of molecular data generated from comprehensive sequencing of cancer samples requires advanced interpretative platforms as precision oncology expands beyond individual patients to entire...