Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 46; no. 3; pp. 673 - 682
• Main Authors: Stertz, Laura, Di Re, Jessica, Pei, Guangsheng, Fries, Gabriel R., Mendez, Emily, Li, Shenglan, Smith-Callahan, Laura, Raventos, Henriette, Tipo, Jerricho, Cherukuru, Rohan, Zhao, Zhongming, Liu, Ying, Jia, Peilin, Laezza, Fernanda, Walss-Bass, Consuelo
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.02.2021; Springer International Publishing
• Subjects: 1-Phosphatidylinositol 3-kinase; Cell lines; Enzyme inhibitors; Fibroblast growth factors; Gene expression; Genomics; Glucocorticoids; Glycogen; Glycogen synthase kinase 3; Glycogen Synthase Kinase 3 - genetics; Humans; Kinases; Mental disorders; Neural Stem Cells; Neurons; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Pluripotency; Ribonucleic acid; Risk factors; RNA; Schizophrenia; Schizophrenia - genetics; Signal transduction; Stem cells; Transcriptomes; Tubulin

Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular models of psychiatric disorders that account for a patient’s genetic background. Here, we conducted an RNA-sequencing profiling study of hiPSC-derived cell lines from schizophrenia (SCZ) subjects, most of whi...