Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation

• Published in: American journal of respiratory and critical care medicine Vol. 190; no. 11; pp. 1243 - 1254
• Main Authors: Qing, Danielle Y., Conegliano, David, Shashaty, Michael G. S., Seo, Jeongyun, Reilly, John P., Worthen, G. Scott, Huh, Dongeun, Meyer, Nuala J., Mangalmurti, Nilam S.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.12.2014
• Subjects: Animals; Blood; Cell death; Critical Illness; Disease Models, Animal; Endothelial Cells - pathology; Erythrocyte Transfusion - adverse effects; HMGB1 Protein - immunology; HMGB1 Protein - physiology; Human subjects; Humans; In Vitro Techniques; Inflammation; Kinases; Lung - pathology; Mice; Middle Aged; Necrosis; Original; Plasma; Pneumonia - etiology; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - etiology; Sepsis; HMGB1; RBC transfusion; RIP3; endothelial; necroptosis

Red blood cell (RBC) transfusions are associated with increased risk of acute respiratory distress syndrome (ARDS) in the critically ill, yet the mechanisms for enhanced susceptibility to ARDS conferred by RBC transfusions remain unknown. To determine the mechanisms of lung endothelial cell (EC) Hig...