Krüppel-like Factor 4 is Required for the Expression of Vascular Smooth Muscle Cell Differentiation Marker Genes Induced by All-Trans Retinoic Acid

• Published in: Journal of biochemistry (Tokyo) Vol. 144; no. 3; pp. 313 - 321
• Main Authors: Wang, Chao, Han, Mei, Zhao, Xin-Ming, Wen, Jin-Kun
• Format: Journal Article
• Language: English
• Published: England Japanese Biochemical Society 01.09.2008; Oxford University Press
• Subjects: all-trans retinoic acid; Animals; Cell Differentiation; Cell Movement; Cell Proliferation; expression; Gene Expression Regulation; Humans; KLF4; Kruppel-Like Transcription Factors - metabolism; Kruppel-Like Transcription Factors - physiology; Male; marker gene; Mice; Models, Biological; Muscle, Smooth, Vascular - cytology; Rats; Rats, Sprague-Dawley; Time Factors; Tretinoin - metabolism; VSMC; all-trans retinoic acid; expression; VSMC; KLF4; marker gene

Krüppel-like factor 4 (KLF4) is involved in phenotypic modulation of vascular smooth muscle cells (VSMCs). All-trans retinoic acid (ATRA) inhibits VSMC proliferation and induces VSMC differentiation. However, the role of KLF4 in ATRA-elicited VSMC phenotypic modulation remains unclear. Here, we show...