Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells

• Published in: Biochimica et biophysica acta Vol. 1861; no. 1; pp. 3002 - 3010
• Main Authors: Thangamani, Shankar, Eldesouky, Hassan E., Mohammad, Haroon, Pascuzzi, Pete E., Avramova, Larisa, Hazbun, Tony R., Seleem, Mohamed N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2017
• Subjects: Animals; Antifungal activity; Antifungal Agents - pharmacology; antifungal properties; Azoles - pharmacology; C. elegans; Caenorhabditis elegans; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - microbiology; Candida - cytology; Candida - drug effects; Candida - growth & development; Candida albicans; Candida parapsilosis; Cryptococcus - cytology; Cryptococcus - drug effects; Cryptococcus - growth & development; Cryptococcus neoformans; drugs; Ebselen; fluconazole; flucytosine; fungi; Glutathione; Glutathione - biosynthesis; Glutathione - pharmacology; homeostasis; inoculum; Kinetics; mechanism of action; Microbial Sensitivity Tests; Microbial Viability - drug effects; Organoselenium Compounds - pharmacology; reactive oxygen species; Reactive Oxygen Species - metabolism; ROS production; Antifungal activity; C. elegans; Ebselen; ROS production; Glutathione

Ebselen, an organoselenium compound and a clinically safe molecule has been reported to possess potent antifungal activity, but its antifungal mechanism of action and in vivo antifungal activity remain unclear. The antifungal effect of ebselen was tested against Candida albicans, C. glabrata, C. tro...