Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells - Thangamani, Shankar; Eldesouky, Hassan E.; Mohammad, Haroon; Pascuzzi, Pete E.; Avramova, Larisa; Hazbun, Tony R.; Seleem, Mohamed N. (Biochimica et biophysica acta, 2017)
Keywords: Animals; Antifungal activity; Antifungal Agents - pharmacology; antifungal properties; Azoles - pharmacology; C. elegans; Caenorhabditis elegans; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - microbiology; Candida - cytology; Candida - drug effects; Candida - growth & development; Candida albicans; Candida parapsilosis; Cryptococcus - cytology; Cryptococcus - drug effects; Cryptococcus - growth & development; Cryptococcus neoformans; drugs; Ebselen; fluconazole; flucytosine; fungi; Glutathione; Glutathione - biosynthesis; Glutathione - pharmacology; homeostasis; inoculum; Kinetics; mechanism of action; Microbial Sensitivity Tests; Microbial Viability - drug effects; Organoselenium Compounds - pharmacology; reactive oxygen species; Reactive Oxygen Species - metabolism; ROS production; Antifungal activity; C. elegans; Ebselen; ROS production; Glutathione