G-quadruplex-based aptamers against protein targets in therapy and diagnostics

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1429 - 1447
• Main Authors: Platella, Chiara, Riccardi, Claudia, Montesarchio, Daniela, Roviello, Giovanni N., Musumeci, Domenica
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: Animals; Anticoagulants - chemistry; Anticoagulants - metabolism; Anticoagulants - therapeutic use; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - therapeutic use; Antiviral Agents - chemistry; Antiviral Agents - metabolism; Antiviral Agents - therapeutic use; Aptamer; Aptamers, Nucleotide - chemistry; Aptamers, Nucleotide - metabolism; Aptamers, Nucleotide - therapeutic use; bacteria; Binding Sites; Biosensing Techniques; diagnostic techniques; Diagnostics; Drug Carriers; G-quadruplex; G-Quadruplexes; genome; Guanosine - chemistry; Guanosine - metabolism; high-throughput nucleotide sequencing; Humans; ions; Ligands; oligonucleotides; Predictive Value of Tests; Protein Binding; Protein target; proteins; RNA; SELEX; SELEX Aptamer Technique; single-stranded DNA; Structure-Activity Relationship; systematic evolution of ligands by exponential enrichment; therapeutics; Therapy; viruses; QDs; Therapy; RT; NECEEM; TPA; Diagnostics; ALP; SARS-CoV; AuNP; PPK; G4; SA; Protein target; GOx; TBA; PDDA; SPR; AMC; TMPG; AGR2; ON; SELEX; VEGF; TBDPS; G-quadruplex; GCE; GO; TMB; KCE; ECL; FAM; SOMAmers; HIV; CND; QCM; TEL; Aptamer; TMPyP4; ABTS; PET

Nucleic acid aptamers are single-stranded DNA or RNA molecules identified to recognize with high affinity specific targets including proteins, small molecules, ions, whole cells and even entire organisms, such as viruses or bacteria. They can be identified from combinatorial libraries of DNA or RNA...