Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV - Tebas, Pablo; Stein, David; Binder-Scholl, Gwendolyn; Mukherjee, Rithun; Brady, Troy; Rebello, Tessio; Humeau, Laurent; Kalos, Michael; Papasavvas, Emmanouil; Montaner, Luis J.; Schullery, Daniel; Shaheen, Farida; et al. (Blood, 2013)
Keywords: Adoptive Transfer - methods; Adult; Antiviral Agents - adverse effects; Antiviral Agents - metabolism; Antiviral Agents - pharmacology; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - physiology; CD4-Positive T-Lymphocytes - transplantation; Clinical Trials and Observations; Female; Gene Therapy; Genetic Therapy - adverse effects; Genetic Therapy - methods; Genetic Vectors - adverse effects; Genetic Vectors - metabolism; Genetic Vectors - pharmacology; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - therapy; HIV-1 - genetics; HIV-1 - immunology; Human immunodeficiency virus; Humans; Immunobiology; Lentivirus - genetics; Lentivirus - metabolism; Lentivirus - physiology; Male; Middle Aged; Oligonucleotides - administration & dosage; Oligonucleotides - genetics; Oligonucleotides, Antisense - administration & dosage; Oligonucleotides, Antisense - adverse effects; Oligonucleotides, Antisense - genetics; Oligonucleotides, Antisense - pharmacology; Transduction, Genetic - methods; Viral Load - drug effects; Virus Replication - genetics