Extracellular matrix proteoglycans support aged hippocampus networks: a potential cellular-level mechanism of brain reserve

• Published in: Neurobiology of aging Vol. 131; pp. 52 - 58
• Main Authors: Gray, Daniel T., Zempare, Marc, Carey, Natalie, Khattab, Salma, Sinakevitch, Irina, De Biase, Lindsay M., Barnes, Carol A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2023
• Subjects: CA3; Cognitive aging; Lipofuscin; Resilience; Spatial memory; Cognitive aging; Lipofuscin; CA3; Resilience; Spatial memory

One hallmark of normative brain aging is vast heterogeneity in whether older people succumb to or resist cognitive decline. Resilience describes a brain’s capacity to maintain cognition in the face of aging and disease. One factor influencing resilience is brain reserve—the status of neurobiological...