Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis

• Published in: Nature communications Vol. 9; no. 1; pp. 3043 - 10
• Main Authors: Yang, Yaping, Lin, Yuheng, Wang, Jian, Wu, Yifei, Zhang, Ruihua, Cheng, Mengyin, Shen, Xiaolin, Wang, Jia, Chen, Zhenya, Li, Chenyi, Yuan, Qipeng, Yan, Yajun
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 02.08.2018; Nature Publishing Group UK; Nature Portfolio
• Subjects: Bacteria - metabolism; Biosynthesis; Control systems; Down-Regulation; Dynamic control; E coli; Escherichia coli - metabolism; Fluorescence; Metabolic Engineering; Metabolism; Microorganisms; Muconic acid; Phenotypes; Promoter Regions, Genetic - genetics; RNA Interference; RNA-mediated interference; Sorbic Acid - analogs & derivatives; Sorbic Acid - metabolism

Writing artificial logic and dynamic function into complex cellular background to achieve desired phenotypes or improved outputs calls for the development of new genetic tools as well as their innovative use. In this study, we present a sensor-regulator and RNAi-based bifunctional dynamic control ne...