Size and surface charge characterization of nanoparticles with a salt gradient

• Published in: Nature communications Vol. 11; no. 1; p. 2337
• Main Authors: Rasmussen, Martin K, Pedersen, Jonas N, Marie, Rodolphe
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 11.05.2020; Nature Publishing Group UK; Nature Portfolio
• Subjects: Biological properties; Biological samples; Biomarkers; Central nervous system; Central nervous system diseases; Exosomes; Lipids; Nanoparticles; Polymers; Purification; Salts; Spatial distribution; Surface charge; Surface properties; Zeta potential

Exosomes are nanometer-sized lipid vesicles present in liquid biopsies and used as biomarkers for several diseases including cancer, Alzheimer's, and central nervous system diseases. Purification and subsequent size and surface characterization are essential to exosome-based diagnostics. Sample...