PTPσ inhibitors promote hematopoietic stem cell regeneration

• Published in: Nature communications Vol. 10; no. 1; pp. 3667 - 15
• Main Authors: Zhang, Yurun, Roos, Martina, Himburg, Heather, Termini, Christina M, Quarmyne, Mamle, Li, Michelle, Zhao, Liman, Kan, Jenny, Fang, Tiancheng, Yan, Xiao, Pohl, Katherine, Diers, Emelyne, Jin Gim, Hyo, Damoiseaux, Robert, Whitelegge, Julian, McBride, William, Jung, Michael E, Chute, John P
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 14.08.2019; Nature Publishing Group UK; Nature Portfolio
• Subjects: 5-Fluorouracil; Allosteric properties; Allosteric Regulation; Animals; Antimetabolites, Antineoplastic - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - radiation effects; Bcl-x protein; bcl-X Protein - drug effects; bcl-X Protein - metabolism; Chemotherapy; Clinical medicine; Competition; Enzyme Inhibitors - pharmacology; Enzyme kinetics; Fluorouracil - pharmacology; Growth factors; Hematopoietic stem cells; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - radiation effects; Humans; In vivo methods and tests; Inhibitors; Mice; Oncology; Phosphatase; Protein-tyrosine-phosphatase; Proteins; rac1 GTP-Binding Protein - drug effects; rac1 GTP-Binding Protein - metabolism; Rac1 protein; Radiation; Radiation effects; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - antagonists & inhibitors; Recovery; Regeneration; Regeneration - drug effects; Regeneration - radiation effects; Repopulation; rho GTP-Binding Proteins - drug effects; rho GTP-Binding Proteins - metabolism; Stem cell transplantation; Stem cells; Tyrosine

Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecule inhibitors of PTPσ that promote HSC regeneration...