Dendritic spine and synapse pathology in chromatin modifier-associated autism spectrum disorders and intellectual disability

• Published in: Frontiers in molecular neuroscience Vol. 15; p. 1048713
• Main Authors: Ford, Thomas James L., Jeon, Byeong Tak, Lee, Hyunkyoung, Kim, Woo-Yang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 19.01.2023; Frontiers Media S.A
• Subjects: Animal models; ARID1B; Autism; Behavior; Brain research; Chromatin remodeling; Dendritic plasticity; dendritic spine; Dendritic spines; Gene expression; Intellectual disabilities; KANSL1; Molecular modelling; Morphogenesis; Morphology; Mutation; Neurodevelopmental disorders; Neuroscience; Proteins; Susceptibility; synapse; WDR5; KANSL1; WDR5; dendritic spine; synapse; ARID1B; autism; intellectual disability

Formation of dendritic spine and synapse is an essential final step of brain wiring to establish functional communication in the developing brain. Recent findings have displayed altered dendritic spine and synapse morphogenesis, plasticity, and related molecular mechanisms in animal models and post-...