ADAR1-mediated regulation of melanoma invasion

• Published in: Nature communications Vol. 9; no. 1; pp. 2154 - 13
• Main Authors: Nemlich, Yael, Baruch, Erez Nissim, Besser, Michal Judith, Shoshan, Einav, Bar-Eli, Menashe, Anafi, Liat, Barshack, Iris, Schachter, Jacob, Ortenberg, Rona, Markel, Gal
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 31.05.2018; Nature Publishing Group UK; Nature Portfolio
• Subjects: 3' Untranslated Regions - genetics; Adenosine Deaminase - genetics; Adenosine Deaminase - metabolism; Antibodies; Cancer; Cell Line, Tumor; Cell migration; Control; DNA microarrays; Editing; Gene expression; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Immunohistochemistry; Integrin beta3 - genetics; Integrin beta3 - metabolism; Invasiveness; Melanoma; Melanoma - genetics; Melanoma - metabolism; Melanoma - pathology; Metastases; MicroRNAs - genetics; Neoplasm Invasiveness; Neoplasm Metastasis; Pax6 protein; Post-transcription; Regulators; Ribonucleic acid; RNA; RNA Editing; RNA Interference; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Transcription factors

Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation. Here we show that ADAR1 silencing enhanc...