Interferon-γ Activates Expression of p15 and p16 Regardless of 9p21.3 Coronary Artery Disease Risk Genotype - Almontashiri, Naif A.M.; Fan, Meng; Cheng, Brian L.M.; Chen, Hsiao-Huei; Roberts, Robert; Stewart, Alexandre F.R. (Journal of the American College of Cardiology, 2013)
Keywords: 9p21.3; Biological and medical sciences; Blotting, Northern; Cardiology. Vascular system; Cardiovascular; Cells, Cultured; Chromosomes, Human, Pair 9 - genetics; coronary artery disease; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Coronary heart disease; cyclin-dependent kinase inhibitor; Cyclin-Dependent Kinase Inhibitor p15 - genetics; Cyclin-Dependent Kinase Inhibitor p15 - metabolism; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; DNA Primers - chemistry; Gene Expression; Genotype; Heart; HEK293 Cells - drug effects; HeLa Cells - drug effects; Human Umbilical Vein Endothelial Cells - drug effects; Humans; Immunoblotting; Interferon-gamma - pharmacology; interferon-γ; Medical sciences; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; p15; p16; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Assessment; RNA, Messenger - metabolism; coronary artery disease; interferon-γ; p16; LCL; SNP; p15; CAD; HAoSMC; HUVEC; cyclin-dependent kinase inhibitor; 9p21.3; PCR; single nucleotide polymorphism; lymphoblastoid cell; human primary aortic smooth muscle cells; human umbilical vein endothelial cell; polymerase chain reaction; Typing; Cardiovascular disease; Genotype; Risk; Gene expression; Coronary heart disease; CDKN2 gene; Microbiological investigation; Risk factor; Circulatory system; Cardiology; Tumor suppressor gene; Gamma interferon