Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects

Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a...

Full description

Saved in:
Bibliographic Details
Published inJournal of nanobiotechnology Vol. 20; no. 1; pp. 224 - 22
Main Authors Wu, Kai, Mohsin, Ali, Zaman, Waqas Qamar, Zhang, Zefei, Guan, Wenyan, Chu, Maoquan, Zhuang, Yingping, Guo, Meijin
Format Journal Article
LanguageEnglish
Published England BioMed Central 12.05.2022
BMC
Subjects
Animal research
Apoptosis
Biocompatibility
Cancer
Cancer therapies
Chemotherapy
Fever
Hyperthermia
Infrared lasers
Iron oxides
Laryngeal cancer
Laryngocarcinoma therapy
Lasers
Magnetic fields
Magnetic materials
Magneto-mechanic force
Medical research
Microspheres
Morphology
Nanomaterials
Nanoparticles
Nanotechnology
Photodynamic effect
Photodynamic therapy
Photothermal effect
Solid tumors
Synergistic effect
Tumors
Urchin-like hollow magnetic microspheres
Photodynamic effect
Photothermal effect
Laryngocarcinoma therapy
Magneto-mechanic force
Urchin-like hollow magnetic microspheres
Online AccessGet full text

Cover

Abstract Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe O . We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects.
AbstractList Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. Results In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. Conclusions The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects.
Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth.BACKGROUNDMagnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth.In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy.RESULTSIn this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy.The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects.CONCLUSIONSThe biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects.
Abstract Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. Results In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. Conclusions The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects. Graphical Abstract
Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe O . We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects.
ArticleNumber 224
Author Wu, Kai
Zhuang, Yingping
Guo, Meijin
Zaman, Waqas Qamar
Guan, Wenyan
Mohsin, Ali
Zhang, Zefei
Chu, Maoquan
Author_xml – sequence: 1
  givenname: Kai
  surname: Wu
  fullname: Wu, Kai
– sequence: 2
  givenname: Ali
  surname: Mohsin
  fullname: Mohsin, Ali
– sequence: 3
  givenname: Waqas Qamar
  surname: Zaman
  fullname: Zaman, Waqas Qamar
– sequence: 4
  givenname: Zefei
  surname: Zhang
  fullname: Zhang, Zefei
– sequence: 5
  givenname: Wenyan
  surname: Guan
  fullname: Guan, Wenyan
– sequence: 6
  givenname: Maoquan
  surname: Chu
  fullname: Chu, Maoquan
– sequence: 7
  givenname: Yingping
  surname: Zhuang
  fullname: Zhuang, Yingping
– sequence: 8
  givenname: Meijin
  orcidid: 0000-0002-3171-4802
  surname: Guo
  fullname: Guo, Meijin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35549715$$D View this record in MEDLINE/PubMed
BookMark eNp9Ustu1TAQjVARfcAPsECR2LBowO8kGyRUUahUiU1ZWxNnfONLYl_sXKT8Al-N09tWbResxjpzzvHYc06LIx88FsVbSj5S2qhPibJW0oowVhEqKK2WF8UJFXVdcSrl0aPzcXGa0pZkpmDiVXHMpRRtTeVJ8fdnNIPz1eh-YTnBxuPsTDk5E0PaDRgxlTbE0oA3GMs5I7Bbco1hvxnKtHiMG5dWDVqLZi6DLSc0A3hnYFy1Bs_L3RDmsIqnjIHvD0C_eJgelOl18dLCmPDNXT0rbi6_3lx8r65_fLu6-HJdGdGquWokyg5lr7htO2t6i5RIw9EKyZGrhhDBeq6E6IRgQHMfEZreiA4EgOFnxdXBtg-w1bvoJoiLDuD0LRDiRkPMDxpRs-zegjXUMiFMT6ABZFJh27KadD3JXp8PXrt9N2Fv0M8RxiemTzveDXoT_uiWtDVvVTb4cGcQw-89pllPLhkcR_AY9kkzpUTdtJyvd71_Rt2GffT5p1aWkoxLJTLr3eOJHka533gmNAfCuuEU0WrjZphdWAd0o6ZEr-HSh3DpHBl9Gy69ZCl7Jr13_4_oH1zG11c
CitedBy_id crossref_primary_10_1016_j_jcis_2024_07_080
crossref_primary_10_1016_j_heliyon_2023_e19893
crossref_primary_10_1002_adfm_202406950
crossref_primary_10_1016_j_physrep_2023_10_003
crossref_primary_10_1016_j_colsurfa_2023_131485
crossref_primary_10_1016_j_mtadv_2024_100484
crossref_primary_10_1002_tcr_202400179
crossref_primary_10_1039_D3MA01150J
crossref_primary_10_1016_j_biopha_2023_114227
crossref_primary_10_1016_j_actbio_2023_02_033
crossref_primary_10_1016_j_ijbiomac_2025_140318
crossref_primary_10_1039_D4NH00497C
crossref_primary_10_1021_acsanm_2c02014
crossref_primary_10_3390_ma16083020
crossref_primary_10_3724_zdxbyxb_2024_0024
crossref_primary_10_1002_rpm_20240027
crossref_primary_10_3390_jfb15080207
crossref_primary_10_1016_j_matdes_2023_111785
crossref_primary_10_1016_j_mtbio_2024_101213
crossref_primary_10_1002_EXP_20230163
Cites_doi 10.1017/S0022215118001305
10.1002/adfm.201904678
10.3389/fphar.2020.00019
10.1021/acsnano.8b07635
10.2147/IJN.S221496
10.1016/S0925-5214(99)00071-X
10.1016/j.jinorgbio.2020.111329
10.1021/acsami.5b03201
10.1016/S1369-7021(11)70163-8
10.1016/j.colsurfb.2018.10.051
10.1002/smll.202003969
10.1021/acsnano.5b07249
10.1021/acsnano.8b01893
10.1007/s12274-012-0200-y
10.1021/nn406302j
10.1016/j.jmmm.2018.11.083
10.1002/adma.201805919
10.1016/j.biomaterials.2020.120636
10.1002/adfm.201604774
10.1021/acsami.9b11291
10.1002/adma.201901885
10.1021/acs.chemrev.8b00363
10.1016/j.biomaterials.2015.04.006
10.2217/nnm-2018-0346
10.1016/0896-6273(88)90139-0
10.3390/molecules23071567
10.1002/adma.201705673
10.1371/journal.pone.0245350
10.1021/nn506949t
10.1002/adfm.201800310
10.1016/j.apsusc.2021.150025
10.1016/j.jmmm.2018.09.014
10.7150/thno.18352
10.1007/s11051-020-05045-9
10.1016/S1470-2045(02)00818-5
10.1038/nmat3406
10.1126/science.1114849
10.1039/C7TB02941A
10.1038/nnano.2007.418
10.1021/nn100190v
10.1016/j.biomaterials.2011.05.007
10.1002/wnan.36
10.1016/j.biomaterials.2013.01.086
10.1021/nn4017179
10.1186/1471-2164-13-295
10.1016/j.cmpb.2016.03.019
10.1039/C7DT04141A
10.3322/caac.21565
10.1016/j.biomaterials.2014.04.063
10.7150/thno.42564
10.1021/acsanm.1c00027
10.1021/acsami.7b05741
10.1021/ar9000026
10.1002/adfm.201803660
10.1002/adma.200400271
10.1021/acsnano.0c00910
10.1200/JCO.2018.36.15_suppl.e18533
10.3847/1538-4357/aba430
10.1109/TMAG.2010.2046907
10.1038/nmat2591
10.3390/app8010097
10.1021/nn4007048
10.1002/smll.201701274
10.1364/OE.389714
10.1016/j.biomaterials.2021.120866
10.1039/C7SC01462G
10.1002/adhm.201400391
10.1002/smll.201802799
10.1021/acs.nanolett.6b03122
10.1038/nnano.2011.95
10.1016/j.addr.2011.03.008
ContentType Journal Article
Copyright 2022. The Author(s).
2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2022
Copyright_xml – notice: 2022. The Author(s).
– notice: 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2022
DBID AAYXX
CITATION
NPM
3V.
7QO
7TB
7X7
7XB
88E
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
KB.
LK8
M0S
M1P
M7P
P64
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12951-022-01411-y
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Mechanical & Transportation Engineering Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest SciTech Premium Collection Technology Collection Materials Science & Engineering Database
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
ProQuest One
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Biotechnology and BioEngineering Abstracts
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest - Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Mechanical & Transportation Engineering Abstracts
ProQuest Central Essentials
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
Materials Science Database
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Materials Science Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Materials Science & Engineering Collection
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database
MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 1477-3155
EndPage 22
ExternalDocumentID oai_doaj_org_article_2cdf9afc1f244cd0a8ae256e99270bd0
PMC9097396
35549715
10_1186_s12951_022_01411_y
Genre Journal Article
GrantInformation_xml – fundername: Fundamental Research Funds for the Central Universities
  grantid: No.22221818014
– fundername: Fundamental Research Funds for the Central Universities
  grantid: No.22221817014
– fundername: Open Funding Project of State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
  grantid: 2019
– fundername: National Key Research and Development Program of China
  grantid: 2018YFA0900300
– fundername: ;
  grantid: No.22221818014; No.22221817014
– fundername: ;
  grantid: 2019
– fundername: ;
  grantid: 2018YFA0900300
GroupedDBID ---
0R~
29L
2WC
53G
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAYXX
ABDBF
ABJCF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADDVE
ADMLS
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BGLVJ
BHPHI
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
CS3
D1I
DIK
DU5
E3Z
EBD
EBLON
EBS
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
I-F
IAO
IHR
INH
INR
ISR
ITC
ITG
ITH
KB.
KQ8
LK8
M1P
M48
M7P
MM.
M~E
O5R
O5S
OK1
OVT
P2P
PDBOC
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RNS
ROL
RPM
RSV
RVI
SCM
SOJ
SV3
TR2
TUS
UKHRP
WOQ
WOW
XSB
~8M
NPM
PJZUB
PPXIY
PQGLB
3V.
7QO
7TB
7XB
8FD
8FK
AZQEC
DWQXO
FR3
GNUQQ
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c496t-85e5be5d63f9bfcdfe105c3ef453e3680042d3644b442a1dfeeea8dc4ba4aac3
IEDL.DBID DOA
ISSN 1477-3155
IngestDate Wed Aug 27 01:11:55 EDT 2025
Thu Aug 21 18:30:10 EDT 2025
Fri Jul 11 04:19:27 EDT 2025
Fri Jul 25 19:15:59 EDT 2025
Mon Jul 21 05:57:43 EDT 2025
Thu Apr 24 23:10:04 EDT 2025
Tue Jul 01 01:26:49 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Photodynamic effect
Photothermal effect
Laryngocarcinoma therapy
Magneto-mechanic force
Urchin-like hollow magnetic microspheres
Language English
License 2022. The Author(s).
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c496t-85e5be5d63f9bfcdfe105c3ef453e3680042d3644b442a1dfeeea8dc4ba4aac3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-3171-4802
OpenAccessLink https://doaj.org/article/2cdf9afc1f244cd0a8ae256e99270bd0
PMID 35549715
PQID 2666523564
PQPubID 44676
PageCount 22
ParticipantIDs doaj_primary_oai_doaj_org_article_2cdf9afc1f244cd0a8ae256e99270bd0
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9097396
proquest_miscellaneous_2664789330
proquest_journals_2666523564
pubmed_primary_35549715
crossref_citationtrail_10_1186_s12951_022_01411_y
crossref_primary_10_1186_s12951_022_01411_y
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-05-12
PublicationDateYYYYMMDD 2022-05-12
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-05-12
  day: 12
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Journal of nanobiotechnology
PublicationTitleAlternate J Nanobiotechnology
PublicationYear 2022
Publisher BioMed Central
BMC
Publisher_xml – name: BioMed Central
– name: BMC
References C Monzel (1411_CR55) 2017; 8
ES Cho (1411_CR50) 2012; 11
B Li (1411_CR61) 2020; 16
C Wang (1411_CR72) 2011; 32
YN Li (1411_CR65) 2019; 14
BE Kashevsky (1411_CR19) 2019; 475
A Barbora (1411_CR35) 2021; 16
1411_CR37
X Nie (1411_CR27) 2019; 11
BJ Mai (1411_CR57) 2020; 11
SK Shaw (1411_CR40) 2021; 560
C Wang (1411_CR74) 2013; 7
A Espinosa (1411_CR17) 2016; 10
WW Ying (1411_CR32) 2020; 14
CSSR Kumar (1411_CR41) 2011; 63
MQ Chu (1411_CR33) 2013; 34
JH Lee (1411_CR43) 2011; 6
S Stafford (1411_CR10) 2018; 8
JH Gao (1411_CR23) 2009; 42
Y Gossuin (1411_CR13) 2009; 1
HL Cheng (1411_CR59) 2020; 215
ST Li (1411_CR22) 2012; 13
L Rao (1411_CR63) 2017; 27
WW Wang (1411_CR73) 2018; 28
JM Estelrich (1411_CR15) 2018; 23
E Hutter (1411_CR68) 2004; 16
MH Cho (1411_CR51) 2016; 16
CR Sun (1411_CR11) 2010; 4
A Tijore (1411_CR49) 2021; 275
A Gulzar (1411_CR70) 2018; 47
1411_CR8
E Zhang (1411_CR53) 2014; 8
HR Burachaloo (1411_CR26) 2018; 12
W Feng (1411_CR29) 2019; 31
ZY Liu (1411_CR9) 2018; 6
ZR Stephen (1411_CR12) 2011; 14
J Howard (1411_CR56) 1988; 1
KD Miller (1411_CR1) 2019; 69
Y Liu (1411_CR31) 2019; 29
AH Sun (1411_CR36) 2020; 28
XX Ma (1411_CR20) 2012; 5
LY Zhang (1411_CR67) 2017; 9
A Rajan (1411_CR5) 2020; 22
P Das (1411_CR7) 2019; 174
JH Hu (1411_CR71) 2019; 14
F Mazuel (1411_CR66) 2017; 13
SJ Mousavi (1411_CR21) 2016; 130
DH Kim (1411_CR54) 2010; 9
JS Huang (1411_CR58) 2021; 269
RJ Mannix (1411_CR45) 2008; 3
D Kilinc (1411_CR46) 2015; 4
E Ozbay (1411_CR69) 2006; 311
B Karabulut (1411_CR4) 2018; 132
C Wu (1411_CR48) 2018; 30
M Vinícius-Araújo (1411_CR38) 2021; 4
M Domenech (1411_CR52) 2013; 7
XZ Wu (1411_CR34) 2020; 12
R Zheng (1411_CR62) 2015; 7
RD Corato (1411_CR25) 2015; 9
Y Chen (1411_CR44) 2018; 14
KM Krishnan (1411_CR14) 2010; 46
SZ Zhao (1411_CR64) 2020; 10
J Wahsner (1411_CR24) 2019; 119
K Pujo (1411_CR2) 2018; 135
A Espinosa (1411_CR39) 2018; 28
Y Liu (1411_CR28) 2018; 12
A Čoček (1411_CR3) 2018; 15
ZH Di (1411_CR30) 2019; 31
ZG Zhou (1411_CR18) 2014; 35
P Wust (1411_CR42) 2002; 3
I Pavese (1411_CR6) 2018; 36
YJ Shen (1411_CR47) 2017; 7
LY Zeng (1411_CR60) 2015; 57
A Nikitin (1411_CR16) 2019; 469
References_xml – volume: 132
  start-page: 832
  issue: 9
  year: 2018
  ident: 1411_CR4
  publication-title: J Laryngol Otol
  doi: 10.1017/S0022215118001305
– volume: 29
  start-page: 1904678
  issue: 50
  year: 2019
  ident: 1411_CR31
  publication-title: Adv Funct Mater
  doi: 10.1002/adfm.201904678
– volume: 11
  start-page: 1
  year: 2020
  ident: 1411_CR57
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.00019
– volume: 12
  start-page: 11819
  issue: 12
  year: 2018
  ident: 1411_CR26
  publication-title: ACS Nano
  doi: 10.1021/acsnano.8b07635
– volume: 14
  start-page: 10009
  year: 2019
  ident: 1411_CR71
  publication-title: Int J Nanomedicine
  doi: 10.2147/IJN.S221496
– ident: 1411_CR37
  doi: 10.1016/S0925-5214(99)00071-X
– volume: 215
  start-page: 111329
  year: 2020
  ident: 1411_CR59
  publication-title: J Inorg Biochem
  doi: 10.1016/j.jinorgbio.2020.111329
– volume: 7
  start-page: 15876
  issue: 29
  year: 2015
  ident: 1411_CR62
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.5b03201
– volume: 14
  start-page: 330
  issue: 7–8
  year: 2011
  ident: 1411_CR12
  publication-title: Mater Today
  doi: 10.1016/S1369-7021(11)70163-8
– volume: 174
  start-page: 42
  year: 2019
  ident: 1411_CR7
  publication-title: Colloids Surf B
  doi: 10.1016/j.colsurfb.2018.10.051
– volume: 16
  start-page: 2003969
  issue: 25
  year: 2020
  ident: 1411_CR61
  publication-title: Small
  doi: 10.1002/smll.202003969
– volume: 10
  start-page: 2436
  issue: 2
  year: 2016
  ident: 1411_CR17
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b07249
– volume: 12
  start-page: 4886
  issue: 5
  year: 2018
  ident: 1411_CR28
  publication-title: ACS Nano
  doi: 10.1021/acsnano.8b01893
– volume: 15
  start-page: 6701
  issue: 5
  year: 2018
  ident: 1411_CR3
  publication-title: Oncol Lett
– volume: 5
  start-page: 199
  issue: 3
  year: 2012
  ident: 1411_CR20
  publication-title: Nano Res
  doi: 10.1007/s12274-012-0200-y
– volume: 8
  start-page: 3192
  issue: 4
  year: 2014
  ident: 1411_CR53
  publication-title: ACS Nano
  doi: 10.1021/nn406302j
– volume: 475
  start-page: 216
  year: 2019
  ident: 1411_CR19
  publication-title: J Magn Magn Mate
  doi: 10.1016/j.jmmm.2018.11.083
– volume: 31
  start-page: 1805919
  issue: 5
  year: 2019
  ident: 1411_CR29
  publication-title: Adv Mater
  doi: 10.1002/adma.201805919
– volume: 269
  start-page: 120636
  year: 2021
  ident: 1411_CR58
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120636
– volume: 27
  start-page: 1604774
  issue: 9
  year: 2017
  ident: 1411_CR63
  publication-title: Adv Funct Mater
  doi: 10.1002/adfm.201604774
– volume: 11
  start-page: 31735
  issue: 35
  year: 2019
  ident: 1411_CR27
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.9b11291
– volume: 31
  start-page: 1901885
  issue: 33
  year: 2019
  ident: 1411_CR30
  publication-title: Adv Mater
  doi: 10.1002/adma.201901885
– volume: 119
  start-page: 957
  issue: 2
  year: 2019
  ident: 1411_CR24
  publication-title: Chem Rev
  doi: 10.1021/acs.chemrev.8b00363
– volume: 57
  start-page: 93
  year: 2015
  ident: 1411_CR60
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.04.006
– volume: 14
  start-page: 1493
  issue: 11
  year: 2019
  ident: 1411_CR65
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2018-0346
– volume: 1
  start-page: 189
  issue: 3
  year: 1988
  ident: 1411_CR56
  publication-title: Neuron
  doi: 10.1016/0896-6273(88)90139-0
– volume: 23
  start-page: 1567
  issue: 7
  year: 2018
  ident: 1411_CR15
  publication-title: Molecules
  doi: 10.3390/molecules23071567
– volume: 30
  start-page: e1705673
  issue: 17
  year: 2018
  ident: 1411_CR48
  publication-title: Adv Mater
  doi: 10.1002/adma.201705673
– volume: 16
  start-page: e0245350
  issue: 1
  year: 2021
  ident: 1411_CR35
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0245350
– volume: 135
  start-page: 111
  year: 2018
  ident: 1411_CR2
  publication-title: Eur Ann Otorhinol
– volume: 9
  start-page: 2904
  issue: 3
  year: 2015
  ident: 1411_CR25
  publication-title: ACS Nano
  doi: 10.1021/nn506949t
– volume: 28
  start-page: 1800310
  issue: 22
  year: 2018
  ident: 1411_CR73
  publication-title: Adv Funct Mater
  doi: 10.1002/adfm.201800310
– ident: 1411_CR8
– volume: 560
  start-page: 150025
  year: 2021
  ident: 1411_CR40
  publication-title: Appl Surf Sci
  doi: 10.1016/j.apsusc.2021.150025
– volume: 469
  start-page: 443
  year: 2019
  ident: 1411_CR16
  publication-title: J Magn Magn Mater
  doi: 10.1016/j.jmmm.2018.09.014
– volume: 7
  start-page: 1735
  issue: 6
  year: 2017
  ident: 1411_CR47
  publication-title: Theranostics.
  doi: 10.7150/thno.18352
– volume: 22
  start-page: 319
  year: 2020
  ident: 1411_CR5
  publication-title: J Nanopart Res
  doi: 10.1007/s11051-020-05045-9
– volume: 3
  start-page: 487
  issue: 8
  year: 2002
  ident: 1411_CR42
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(02)00818-5
– volume: 11
  start-page: 978
  issue: 11
  year: 2012
  ident: 1411_CR50
  publication-title: Nat Mater
  doi: 10.1038/nmat3406
– volume: 311
  start-page: 189
  issue: 5758
  year: 2006
  ident: 1411_CR69
  publication-title: Science
  doi: 10.1126/science.1114849
– volume: 6
  start-page: 366
  issue: 3
  year: 2018
  ident: 1411_CR9
  publication-title: J Mater Chem B
  doi: 10.1039/C7TB02941A
– volume: 3
  start-page: 36
  year: 2008
  ident: 1411_CR45
  publication-title: Nat Nanotechnol
  doi: 10.1038/nnano.2007.418
– volume: 4
  start-page: 2402
  issue: 4
  year: 2010
  ident: 1411_CR11
  publication-title: ACS Nano
  doi: 10.1021/nn100190v
– volume: 32
  start-page: 6145
  issue: 26
  year: 2011
  ident: 1411_CR72
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.05.007
– volume: 1
  start-page: 299
  issue: 3
  year: 2009
  ident: 1411_CR13
  publication-title: WIREs Nanomed Nanobiotechnol
  doi: 10.1002/wnan.36
– volume: 34
  start-page: 4078
  issue: 16
  year: 2013
  ident: 1411_CR33
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.01.086
– volume: 7
  start-page: 6782
  issue: 8
  year: 2013
  ident: 1411_CR74
  publication-title: ACS Nano
  doi: 10.1021/nn4017179
– volume: 13
  start-page: 295
  year: 2012
  ident: 1411_CR22
  publication-title: BMC Genom
  doi: 10.1186/1471-2164-13-295
– volume: 130
  start-page: 106
  year: 2016
  ident: 1411_CR21
  publication-title: Comput Methods Programs Biomed
  doi: 10.1016/j.cmpb.2016.03.019
– volume: 47
  start-page: 3931
  issue: 11
  year: 2018
  ident: 1411_CR70
  publication-title: Dalton Trans
  doi: 10.1039/C7DT04141A
– volume: 69
  start-page: 363
  issue: 5
  year: 2019
  ident: 1411_CR1
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21565
– volume: 35
  start-page: 7470
  issue: 26
  year: 2014
  ident: 1411_CR18
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.04.063
– volume: 10
  start-page: 6278
  issue: 14
  year: 2020
  ident: 1411_CR64
  publication-title: Theranostics
  doi: 10.7150/thno.42564
– volume: 4
  start-page: 2190
  issue: 2
  year: 2021
  ident: 1411_CR38
  publication-title: ACS Appl Nano Mater
  doi: 10.1021/acsanm.1c00027
– volume: 9
  start-page: 26665
  issue: 32
  year: 2017
  ident: 1411_CR67
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.7b05741
– volume: 42
  start-page: 1097
  issue: 8
  year: 2009
  ident: 1411_CR23
  publication-title: Acc Chem Res
  doi: 10.1021/ar9000026
– volume: 28
  start-page: 1803660
  issue: 37
  year: 2018
  ident: 1411_CR39
  publication-title: Adv Funct Mater
  doi: 10.1002/adfm.201803660
– volume: 16
  start-page: 1685
  issue: 19
  year: 2004
  ident: 1411_CR68
  publication-title: Adv Mater
  doi: 10.1002/adma.200400271
– volume: 14
  start-page: 9662
  issue: 8
  year: 2020
  ident: 1411_CR32
  publication-title: ACS Nano
  doi: 10.1021/acsnano.0c00910
– volume: 36
  start-page: e18533
  issue: 15
  year: 2018
  ident: 1411_CR6
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2018.36.15_suppl.e18533
– volume: 12
  start-page: 38
  year: 2020
  ident: 1411_CR34
  publication-title: Nanomicro Lett
  doi: 10.3847/1538-4357/aba430
– volume: 46
  start-page: 2523
  issue: 7
  year: 2010
  ident: 1411_CR14
  publication-title: IEEE Trans Magn
  doi: 10.1109/TMAG.2010.2046907
– volume: 9
  start-page: 165
  issue: 2
  year: 2010
  ident: 1411_CR54
  publication-title: Nat Mater
  doi: 10.1038/nmat2591
– volume: 8
  start-page: 97
  issue: 1
  year: 2018
  ident: 1411_CR10
  publication-title: Appl Sci
  doi: 10.3390/app8010097
– volume: 7
  start-page: 5091
  issue: 6
  year: 2013
  ident: 1411_CR52
  publication-title: ACS Nano
  doi: 10.1021/nn4007048
– volume: 13
  start-page: 1701274
  issue: 31
  year: 2017
  ident: 1411_CR66
  publication-title: Small
  doi: 10.1002/smll.201701274
– volume: 28
  start-page: 9002
  issue: 6
  year: 2020
  ident: 1411_CR36
  publication-title: Opt Express
  doi: 10.1364/OE.389714
– volume: 275
  start-page: 120866
  year: 2021
  ident: 1411_CR49
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.120866
– volume: 8
  start-page: 7330
  issue: 11
  year: 2017
  ident: 1411_CR55
  publication-title: Chem Sci
  doi: 10.1039/C7SC01462G
– volume: 4
  start-page: 395
  issue: 3
  year: 2015
  ident: 1411_CR46
  publication-title: Adv Healthc Mater
  doi: 10.1002/adhm.201400391
– volume: 14
  start-page: e1802799
  issue: 45
  year: 2018
  ident: 1411_CR44
  publication-title: Small
  doi: 10.1002/smll.201802799
– volume: 16
  start-page: 7455
  issue: 12
  year: 2016
  ident: 1411_CR51
  publication-title: Nano Lett
  doi: 10.1021/acs.nanolett.6b03122
– volume: 6
  start-page: 418
  year: 2011
  ident: 1411_CR43
  publication-title: Nat Nanotechnol
  doi: 10.1038/nnano.2011.95
– volume: 63
  start-page: 789
  issue: 9
  year: 2011
  ident: 1411_CR41
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2011.03.008
SSID ssj0022424
Score 2.3928535
Snippet Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into...
Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates...
Abstract Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 224
SubjectTerms Animal research
Apoptosis
Biocompatibility
Cancer
Cancer therapies
Chemotherapy
Fever
Hyperthermia
Infrared lasers
Iron oxides
Laryngeal cancer
Laryngocarcinoma therapy
Lasers
Magnetic fields
Magnetic materials
Magneto-mechanic force
Medical research
Microspheres
Morphology
Nanomaterials
Nanoparticles
Nanotechnology
Photodynamic effect
Photodynamic therapy
Photothermal effect
Solid tumors
Synergistic effect
Tumors
Urchin-like hollow magnetic microspheres
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagXOCAeJNSkJG4QdQ8bCc-IUBUFRKcWmlvlmOP24pusmy2h_0L_OrOON5tF6Fe_ZCczIz9jT3zDWMfrC5A-RqdnK7ocqF9nXdKulxaHyAUUIeWkpN__lLHp-LHTM7ShduYwio3e2LcqP3g6I78EA8ShU6TVOLz4k9OVaPodTWV0LjPHhB1GYV0NbMbh4tSHzaJMq06HPFsk-g8VxSMIMoyX-8cRpGz_39A8994yVsH0NET9jghR_5lEvVTdg_6Z-zRLT7B5-zvKT0L9PnlxW_gc3vWU4Yin1PM3Uj0ATByxKjckaSXfEq9WvNUqoePa8oDjMTNfArz4EPgc6DcYBIlzXXwiS_Oh1XM25pjm-391OCn0vZp5viCnRx9P_l2nKdiC7kTWq3yVoLsQHpVB90Fh5JC5OVqCELWUKuWrNvXiJ46ISpbYj-Abb0TnRXWuvol2-uHHl4zjhgBClF6hE5S-E5rD21ArwqRqEPvy2Ws3Px04xIROdXDuDTRIWmVmQRlUFAmCsqsM_ZxO2cx0XDcOforyXI7kii0Y8OwPDPJIk2F36htcGVAhON8YVsLiP9A66opOl9k7GCjCSbZ9WhutDBj77fdaJH0zGJ7GK7iGNG0dFGUsVeT4mxXQuhON6XMWLOjUjtL3e3pL84j67cmYiWt9u9e1hv2sIoKLvOyOmB7q-UVvEXYtOreRdu4BijGHKk
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZKucAB8SZQkJG4QSAP24kPCAGiqpDKqSv1FvkxaavuJmWzlchf4Fcz4zzURStOXG2PZGdm5G_imW8Ye2N0AsrnGOTYxMZC-zy2SrpYGl9DnUBel1ScfPxDHS3E91N5usemdkfjB-x2hnbUT2qxXr7_9bP_hA7_MTh8qT50eGdJDIozSjIQaRr3t9htvJkKctRjMb8qZFQKMRXO7JTbupwCh_8u4Pl3_uSNC-nwPrs3Ikn-eVD9A7YHzUN29wa_4CP2e0HPBE28vLgEvjJnDVUs8hXl4HVEJwAdR8zKHWl-zYdSrJ6PrXt411NdYCBy5kPaB29rvgKqFSbVkqyDd_zqvN2EOq4VjpnGDwN-aHU_SnaP2cnht5OvR_HYfCF2QqtNXEqQFqRXea1t7VBziMRcDrWQOeSqJG_3OaIpK0RmUpwHMKV3whphjMufsP2mbeAZ44gZIBGpRyglhbdaeyhrjLIQmTqMxlzE0umjV24kJqf-GMsqBCilqgZFVaioKiiq6iP2dpa5Gmg5_rn6C-lyXkmU2mGgXZ9Vo4dWGZ5Rm9qlNSIe5xNTGkA8CFpnRWJ9ErGDyRKqyUwrhDcKQ3mpRMRez9PoofTsYhpor8MaUZT04yhiTwfDmXdCaE8XqYxYsWVSW1vdnmkuzgMLuCaiJa2e_4-zvWB3suAGMk6zA7a_WV_DSwRbG_sqeNAfTAwtmw
  priority: 102
  providerName: Scholars Portal
Title Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects
URI https://www.ncbi.nlm.nih.gov/pubmed/35549715
https://www.proquest.com/docview/2666523564
https://www.proquest.com/docview/2664789330
https://pubmed.ncbi.nlm.nih.gov/PMC9097396
https://doaj.org/article/2cdf9afc1f244cd0a8ae256e99270bd0
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagXOCAeBMoKyNxg6h52I59pKhLhdQKoVbaW-TYY1rRzVbN9rB_gV_NjJ1d7SIEFy45-CE5nhnNN8nMN4y9s6YA5WsMcrqiy4Xxdd4p6XJpfYBQQB00FSefnKrjc_FlJmdbrb4oJyzRA6eLO6icD8YGVwZ0RM4XVltANw3GVE3R-Rito89bB1NjqEVFD-sSGa0OBvRqEsPmitIQRFnmqx03FNn6_wQxf8-U3HI900fs4YgZ-cd01sfsDvRP2IMtJsGn7Oc5_RDo86vLH8Dn9ntPtYl8Ttl2AxEHwMARnXJHMr7hqehqxccmPXxYUQVgpGzmKcGDLwKfA1UFkxBpr4MP_PpisYwVW3Mcs71PAz41tR93Ds_Y2fTo7NNxPrZZyJ0waplrCbID6VUdTBfwugExl6shCFlDrTTZta8RN3VCVLbEeQCrvROdFda6-jnb6xc9vGQc0QEUovQImqTwnTEedMB4CjGow7jLZaxcX3rrRgpy6oRx1cZQRKs2CapFQbVRUO0qY-83e64TAcdfVx-SLDcriTw7DqBKtaNKtf9SqYztrzWhHS16aBHIKAzapRIZe7uZRlukHyy2h8VtXCMaTZ-IMvYiKc7mJITrTFPKjDU7KrVz1N2Z_vIi8n0bolQy6tX_eLfX7H4VzUDmZbXP9pY3t_AGYdWym7C7zazBp55-nrB7h0enX79NolXh80ToX2YVKo0
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLZKOQAHxE6ggJHgBFGz2J74gBBbNaXLaSrNzXLsl7aikwyTqVD-Av-F_8h7WaYdhHrr1Uvk5H1-_l78FsbeWB2B8ikaOXmUh0L7NMyVdKG0voAigrTIKDj54FCNj8T3qZxusD9DLAy5VQ46sVXUvnL0j3wbDxKFRpNU4uP8Z0hVo-h2dSih0cFiD5pfaLLVH3a_onzfJsnOt8mXcdhXFQid0GoZZhJkDtKrtNB54XBJSDFcCoWQKaQqIxj7FGlCLkRiY-wHsJl3IrfCWpfiY2-wm3juRrShRtML-44iLYa4nExt13iUSrTVE_J9EHEcNmtnX1si4H-89l_3zEvn3c49drcnqvxTh6z7bAPKB-zOpfSFD9nvI7qFKMOz0x_AZ_a4pIBIPiMXv5qyFUDNkRJzR8Ba8C7Sq-F9ZSBeNxR22OaJ5p1XCa8KPgMKRSbk0FwH7_n8pFq2YWIzbLOl7xp8U9rZamb9iE2uQwqP2WZZlfCUcaQkEInYI1OTwudae8gKNOKQ-Do09lzA4uGjG9fnPafyG2emtX8yZTpBGRSUaQVlmoC9W82Zd1k_rhz9mWS5GkkZu9uGanFsegVgEnxHbQsXF0ionI9sZgHpJmidjKLcRwHbGpBgejVSmwvQB-z1qhsVAN3q2BKq83aMGGX0XypgTzrgrFZCZFKPYhmw0Rqk1pa63lOenrRJxjXlcdLq2dXLesVujScH-2Z_93DvObudtGCXYZxssc3l4hxeIGNb5i_bfcKZueZ9-RdcoFty
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Urchin-like+magnetic+microspheres+for+cancer+therapy+through+synergistic+effect+of+mechanical+force%2C+photothermal+and+photodynamic+effects&rft.jtitle=Journal+of+nanobiotechnology&rft.au=Kai+Wu&rft.au=Ali+Mohsin&rft.au=Waqas+Qamar+Zaman&rft.au=Zefei+Zhang&rft.date=2022-05-12&rft.pub=BMC&rft.eissn=1477-3155&rft.volume=20&rft.issue=1&rft.spage=1&rft.epage=22&rft_id=info:doi/10.1186%2Fs12951-022-01411-y&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_2cdf9afc1f244cd0a8ae256e99270bd0
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1477-3155&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1477-3155&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1477-3155&client=summon