Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis

• Published in: BMC medicine Vol. 19; no. 1; p. 100
• Main Authors: Zhuang, Zhenhuang, Yao, Minhao, Wong, Jason Y Y, Liu, Zhonghua, Huang, Tao
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.04.2021; BMC
• Subjects: Adipose Tissue; Association analysis; Binding sites; Blood vessels; Body fat; Body fat percentage; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Congestive heart failure; Consortia; Coronary artery; Coronary artery disease; Coronary vessels; Correlation analysis; Endocrine system; Estimates; Etiology; Gene expression; Gene loci; Genetic correlation; Genetic Predisposition to Disease; Genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Heart failure; Humans; Linkage disequilibrium; Mendelian randomization; Mendelian Randomization Analysis; Meta-analysis; Phenotype; Polymorphism, Single Nucleotide; Quality control; Shared genetics; Software; Stroke; Tissues; Transcriptomes; Body fat percentage; Genetic correlation; Mendelian randomization; Cardiovascular diseases; Shared genetics

Accumulating evidences have suggested that high body fat percentage (BF%) often occurs in parallel with cardiovascular diseases (CVDs), implying a common etiology between them. However, the shared genetic etiology underlying BF% and CVDs remains unclear. Using large-scale genome-wide association stu...