Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death

• Published in: The Journal of biological chemistry Vol. 281; no. 14; pp. 9616 - 9622
• Main Authors: Westerheide, Sandy D., Kawahara, Tiara L.A., Orton, Kai, Morimoto, Richard I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.04.2006; American Society for Biochemistry and Molecular Biology
• Subjects: Antineoplastic Agents - pharmacology; Cell Death - drug effects; Diterpenes - pharmacology; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - drug effects; Epoxy Compounds; Gene Expression Regulation - drug effects; Heat Shock Transcription Factors; HeLa Cells; HSP70 Heat-Shock Proteins - biosynthesis; HSP70 Heat-Shock Proteins - drug effects; Humans; Phenanthrenes - pharmacology; Promoter Regions, Genetic; Transcription Factors - biosynthesis; Transcription Factors - drug effects; Transcriptional Activation

Molecular chaperones, inducible by heat shock and a variety of other stresses, have critical roles in protein homeostasis, balancing cell stress with adaptation, survival, and cell death mechanisms. In transformed cells and tumors, chaperones are frequently overexpressed, with constitutive activatio...