Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP

• Published in: PLoS computational biology Vol. 4; no. 8; p. e1000148
• Main Authors: Turcotte, Marc, Tang, Wei, Ross, Elliott M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.08.2008; Public Library of Science (PLoS)
• Subjects: Binding, Competitive; Biochemistry/Cell Signaling and Trafficking Structures; Biochemistry/Theory and Simulation; Biophysics/Cell Signaling and Trafficking Structures; Biophysics/Theory and Simulation; Computational Biology/Signaling Networks; Computational Biology/Systems Biology; Enzyme Activation - physiology; Enzyme Inhibitors - metabolism; Enzyme kinetics; GTP-Binding Proteins - chemistry; GTP-Binding Proteins - metabolism; GTPase-Activating Proteins - metabolism; Guanosine Diphosphate - metabolism; Guanosine Triphosphate - metabolism; Hydrolysis; Kinetics; Least-Squares Analysis; Mathematical models; Models, Biological; Phospholipase C beta - metabolism; Protein Binding - physiology; Proteins; Receptors, G-Protein-Coupled - metabolism; Regulation; Signal Transduction; Systems Biology - methods; Unilamellar Liposomes; Up-Regulation; Binding, Competitive; Unilamellar Liposomes; Up-Regulation; Enzyme Inhibitors; GTPase-Activating Proteins; Signal Transduction; Receptors, G-Protein-Coupled; Guanosine Diphosphate; Systems Biology; Hydrolysis; Phospholipase C beta; Models, Biological; Least-Squares Analysis; Protein Binding; Enzyme Activation; GTP-Binding Proteins; Kinetics; Guanosine Triphosphate

Signal output from receptor-G-protein-effector modules is a dynamic function of the nucleotide exchange activity of the receptor, the GTPase-accelerating activity of GTPase-activating proteins (GAPs), and their interactions. GAPs may inhibit steady-state signaling but may also accelerate deactivatio...