Design, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment

• Published in: Scientific reports Vol. 12; no. 1; pp. 12058 - 14
• Main Authors: Sharma, Pratibha, Sharma, Sheetal, Joshi, Shubhi, Barman, Panchali, Bhatt, Aashish, Maan, Mayank, Singla, Neha, Rishi, Praveen, Ali, Md Ehesan, Preet, Simran, Saini, Avneet
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 14.07.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics; Antimicrobial agents; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - pharmacology; Antimicrobial Peptides; Calorimetry; Circular Dichroism; Cytotoxicity; Differential scanning calorimetry; Hemolysis; Humans; Hydrophobicity; Microbial activity; Microbial Sensitivity Tests; Multidrug resistance; Peptides; Physicochemical properties; Spectroscopy; Structure-function relationships

The emergence of multidrug resistance coupled with shrinking antibiotic pipelines has increased the demand of antimicrobials with novel mechanisms of action. Therefore, researchers across the globe are striving to develop new antimicrobial substances to alleviate the pressure on conventional antibio...