Potential antitumor activity of digitoxin and user-designed analog administered to human lung cancer cells - Eldawud, Reem; Wagner, Alixandra; Dong, Chenbo; Gupta, Neha; Rojanasakul, Yon; O'Doherty, George; Stueckle, Todd A.; Dinu, Cerasela Zoica (Biochimica et biophysica acta. General subjects, 2020)
Keywords: adhesion; Anti-tumor activity; antineoplastic activity; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; apoptosis; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - pathology; Cardiac glycosides; Cell Line, Tumor; Cell Movement - drug effects; cell proliferation; Chemotherapy; Cytoskeleton - drug effects; Cytoskeleton - pathology; Digitoxin; Digitoxin - analogs & derivatives; Digitoxin - pharmacology; dose response; epithelium; focal adhesions; gene expression; genes; heart failure; human diseases; Humans; Lung cancer; lung neoplasms; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; lungs; metalloproteinases; microtubules; neoplasm cells; non-specific serine/threonine protein kinase; protein synthesis; signal transduction; Synthetic analog; Therapeutic alternatives; therapeutics; toxicity; BCA; CG; E; Lung cancer; Anti-tumor activity; DEG; AFM; ECIS; DTX; Therapeutic alternatives; Synthetic analog; Cardiac glycosides; MFI; Chemotherapy; Digitoxin; D6MA