Long-term retrospective observation study to evaluate effects of adiponectin on skeletal muscle in renal transplant recipients

• Published in: Scientific reports Vol. 10; no. 1; p. 10723
• Main Authors: Adachi, Hiroki, Fujimoto, Keiji, Fujii, Ai, Yamasaki, Keita, Okada, Keiichiro, Matsuura, Toshikazu, Okino, Kazuaki, Furuichi, Kengo, Yokoyama, Hitoshi
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.07.2020; Nature Publishing Group UK
• Subjects: Adiponectin; Adiponectin - metabolism; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; Adult; Age of Onset; Diabetes mellitus; Diabetes Mellitus - etiology; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Female; Humans; Kidney diseases; Kidney transplantation; Kidney Transplantation - adverse effects; Male; Middle Aged; Molecular weight; Muscle, Skeletal - metabolism; Psoas muscle; Psoas Muscles - metabolism; Psoas Muscles - pathology; Retrospective Studies; Risk Assessment; Risk Factors; Sarcopenia; Sarcopenia - etiology; Sarcopenia - metabolism; Sarcopenia - pathology; Skeletal muscle; Transplant Recipients; Transplants & implants
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-67711-1

Although it has been reported that chronic kidney disease exacerbates sarcopenia progression, the mechanisms of the process remain unclear. Fifty-one patients who underwent renal transplantation at our hospital since 1998 (31 males and 20 females; aged 29-52 years at the time of transplantation) were retrospectively examined for the relationships among the psoas muscle index (PMI), intramuscular adipose tissue content (IMAC), serum adiponectin fractions (high-/low-molecular-weight) and new-onset diabetes after transplantation (NODAT). Before transplantation, age at kidney transplantation negatively correlated with PMI and positively correlated with IMAC (rS = - 0.427, p < 0.01; rS = 0.464, p < 0.01, respectively). Both at 1 and 5 years after transplantation, PMI was higher than before transplantation (p < 0.01). IMAC transiently decreased to - 0.39 at 1 year after kidney transplantation but subsequently increased to - 0.36 at 5 years after kidney transplantation. Multivariate analyses revealed that the mean increase in high-molecular weight adiponectin concentrations was an exacerbating factor for the mean change in PMI (p = 0.003). Moreover, the mean increases in IMAC were exacerbating factors for NODAT. In conclusion, the increase in the PMI is associated with high-molecular weight adiponectin levels after renal transplantation.