The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

• Published in: Science immunology Vol. 5; no. 48
• Main Authors: Premkumar, Lakshmanane, Segovia-Chumbez, Bruno, Jadi, Ramesh, Martinez, David R, Raut, Rajendra, Markmann, Alena, Cornaby, Caleb, Bartelt, Luther, Weiss, Susan, Park, Yara, Edwards, Caitlin E, Weimer, Eric, Scherer, Erin M, Rouphael, Nadine, Edupuganti, Srilatha, Weiskopf, Daniela, Tse, Longping V, Hou, Yixuan J, Margolis, David, Sette, Alessandro, Collins, Matthew H, Schmitz, John, Baric, Ralph S, de Silva, Aravinda M
• Format: Journal Article
• Language: English
• Published: United States 11.06.2020
• Subjects: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral - immunology; Betacoronavirus - immunology; Coronavirus Infections - blood; Coronavirus Infections - diagnosis; Coronavirus Infections - virology; COVID-19; Humans; Immunodominant Epitopes - immunology; Kinetics; Mice; Mice, Inbred BALB C; Pandemics; Pneumonia, Viral - blood; Pneumonia, Viral - diagnosis; Pneumonia, Viral - virology; Protein Binding; Protein Domains - immunology; Rabbits; SARS-CoV-2; Serologic Tests; Severe acute respiratory syndrome-related coronavirus - chemistry; Severe acute respiratory syndrome-related coronavirus - immunology; Spike Glycoprotein, Coronavirus - chemistry; Zoonoses - blood; Zoonoses - virology
• ISSN: 2470-9468
• DOI: 10.1126/sciimmunol.abc8413

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness. People infected with this highly contagious virus can present with clinically inapparent, mild, or severe disease. Currently, the virus infect...