Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

• Published in: Nature communications Vol. 14; no. 1; p. 1305
• Main Authors: Tang, Bo, Tang, Li, Li, Shengpeng, Liu, Shuang, He, Jialin, Li, Pan, Wang, Sumin, Yang, Min, Zhang, Longhui, Lei, Yuanyuan, Tu, Dianji, Tang, Xuefeng, Hu, Hua, Ouyang, Qin, Chen, Xia, Yang, Shiming
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 09.03.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Acids; Animals; Bile; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Colonization; Female; Fetuses; Gallbladder diseases; Gastrointestinal Microbiome; Humans; Intestinal microflora; Liver diseases; Metabolism; Mice; Microbiomes; Microbiota; Pregnancy; Pregnancy Complications - metabolism; Signaling

Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is characterized by increased serum bile acid and adverse fetal outcomes. The aetiology and mechanism of ICP are poorly understood; thus, existing therapies have been largely empiric. Here we show that the gut m...