Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation

• Published in: American journal of respiratory and critical care medicine Vol. 192; no. 11; pp. 1325 - 1334
• Main Authors: Singer, Jonathan P., Diamond, Joshua M., Gries, Cynthia J., McDonnough, Jamiela, Blanc, Paul D., Shah, Rupal, Dean, Monica Y., Hersh, Beverly, Wolters, Paul J., Tokman, Sofya, Arcasoy, Selim M., Ramphal, Kristy, Greenland, John R., Smith, Nancy, Heffernan, Pricilla, Shah, Lori, Shrestha, Pavan, Golden, Jeffrey A., Blumenthal, Nancy P., Huang, Debbie, Sonett, Joshua, Hays, Steven, Oyster, Michelle, Katz, Patricia P., Robbins, Hilary, Brown, Melanie, Leard, Lorriana E., Kukreja, Jasleen, Bacchetta, Matthew, Bush, Errol, D’Ovidio, Frank, Rushefski, Melanie, Raza, Kashif, Christie, Jason D., Lederer, David J.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.12.2015
• Subjects: Activities of Daily Living; Aged; Biomarkers - blood; Case-Control Studies; Cohort Studies; Disabled Persons - statistics & numerical data; Female; Frail Elderly; Geriatric Assessment - methods; Geriatric Assessment - statistics & numerical data; Humans; Insulin-Like Growth Factor I; Interleukin-6 - blood; Leptin - blood; Lung Transplantation; Male; Middle Aged; Original; Phenotype; Postoperative Complications - blood; Postoperative Complications - diagnosis; Postoperative Complications - epidemiology; Prevalence; Prospective Studies; Receptors, Tumor Necrosis Factor - blood; Reproducibility of Results; United States - epidemiology; United States; frailty; body composition; lung transplantation; biomarker; disability

Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined in lung transplantation. To examine the construct and predictive validity of frailty phenotypes in lung transplant candidates. In a multicenter prospective cohort, we measured frailty with...