Glucosylceramide synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line

• Published in: International journal of hematology Vol. 100; no. 6; pp. 559 - 566
• Main Authors: Wang, Qian, Zou, Jian, Zhang, Xiufen, Mu, Huijun, Yin, Ying, Xie, Ping
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.12.2014; Springer; Springer Nature B.V
• Subjects: Antibiotics, Antineoplastic - pharmacology; Apoptosis - drug effects; Apoptosis - genetics; Biological and medical sciences; Butadienes - pharmacology; Doxorubicin - pharmacology; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic - drug effects; Gene Knockdown Techniques; Glucosyltransferases - genetics; Glucosyltransferases - metabolism; Hematologic and hematopoietic diseases; Hematology; Humans; K562 Cells; Leukemia - genetics; Leukemia - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; MAP Kinase Signaling System - drug effects; Medical sciences; Medicine; Medicine & Public Health; Nitriles - pharmacology; Oncology; Original Article; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; RNA Interference; RNA, Small Interfering; Bcl-2; Ceramide; Extracellular signal-regulated kinase; Glucosylceramide synthase; Multidrug resistance; Extracellular signal-regulated protein kinase; Leukemia; Glycosyltransferases; Ceramide glucosyltransferase; Signal transduction; Signaling pathway; Multiple resistance; Protooncogene; Human; Treatment resistance; Hematology; Enzyme; Transferases; Sphingolipid; Mitogen-activated protein kinase; Malignant hemopathy; Extracellular; Kinase; C-Onc gene; Hexosyltransferases; Cancer

Multidrug resistance (MDR) to chemotherapeutic agents is a major obstacle to curative treatment of cancer. In various types of cancers, overexpression of glucosylceramide synthase (GCS) has been observed to be associated with MDR, thus making GCS a target for reversal of resistance. Our previous wor...