Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 5; pp. 950 - 959
• Main Authors: Corteselli, Elizabeth M., Gibbs-Flournoy, Eugene, Simmons, Steven O., Bromberg, Philip, Gold, Avram, Samet, James M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019
• Subjects: adverse effects; catalase; Cells, Cultured; dose response; Dose-Response Relationship, Drug; Glutathione; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione peroxidase 4; Humans; hydrogen peroxide; Hydrogen Peroxide - chemistry; Hydrogen Peroxide - metabolism; Hydroperoxide; image analysis; Lewis acids; Linoleic Acids - metabolism; Linoleic Acids, Conjugated - metabolism; Lipid peroxidation; lipid peroxides; molecular weight; NADP (coenzyme); oxidation; Oxidation-Reduction; pathogenesis; Phospholipid Hydroperoxide Glutathione Peroxidase; polyunsaturated fatty acids; protective effect; redox potential; xenobiotics; 9-HpODE; GPx4; HAEC; EGSH; Lipid peroxidation; Hydroperoxide; TBH; 9-HODE; H2O2; Glutathione; Glutathione peroxidase 4

Peroxidation of PUFAs by a variety of endogenous and xenobiotic electrophiles is a recognized pathophysiological process that can lead to adverse health effects. Although secondary products generated from peroxidized PUFAs have been relatively well studied, the role of primary lipid hydroperoxides i...