Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors

• Published in: Scientific reports Vol. 7; no. 1; pp. 13682 - 11
• Main Authors: Caldwell, Jr, Charles, Johnson, Cory E, Balaji, V N, Balaji, Govardhan A, Hammer, Richard D, Kannan, Raghuraman
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 20.10.2017; Nature Publishing Group UK
• Subjects: Apoptosis; B7-H1 Antigen - metabolism; Biomarkers, Tumor - metabolism; Biotin; Cell Line, Tumor; Flow cytometry; Humans; Immunohistochemistry; Immunosuppressive agents; Lung cancer; Lymphoma; Melanoma; Neoplasms - metabolism; Neoplasms - pathology; Non-small cell lung carcinoma; Patients; PD-1 protein; PD-L1 protein; Peptides; Peptides, Cyclic - metabolism; Protein Binding; Protein Conformation; Sensitivity and Specificity; Squamous cell carcinoma; Tumors

Blocking the interaction between Programmed Death Ligand 1 (PD-L1) and its receptor, PD-1, is an effective method of treating many types of cancers. Certain tumors overexpress PD-L1, causing host immune cells that express PD-1 to bind PD-L1 and cease killing the tumor. Inhibition of PD-L1 and PD-1 b...