Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 11; pp. 2417 - 2426
• Main Authors: Hu, Xin, Chandler, Joshua D., Fernandes, Jolyn, Orr, Michael L., Hao, Li, Uppal, Karan, Neujahr, David C., Jones, Dean P., Go, Young-Mi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2018
• Subjects: amino acid metabolism; bioinformatics; biostatistics; cadmium; Cadmium burden; cadmium chloride; data analysis; Dietary supplement; drinking water; feed supplements; genes; immunoglobulins; Integrative omics; lungs; metabolites; metabolome; metabolomics; mice; muscle development; Nutritional requirements; protective effect; selenium; Selenium metabolism; toxicity; transcriptome; transcriptomics; transferases; urea cycle; Cadmium burden; Dietary supplement; Selenium metabolism; Nutritional requirements; Integrative omics

The protective effect of selenium (Se) on cadmium (Cd) toxicity is well documented, but underlying mechanisms are unclear. Male mice fed standard diet were given Cd (CdCl2, 18 μmol/L) in drinking water with or without Se (Na2SeO4, 20 μmol/L) for 16 weeks. Lungs were analyzed for Cd concentration, tr...