Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells
Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolo...
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Published in | Communications biology Vol. 5; no. 1; p. 458 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group
13.05.2022
Nature Publishing Group UK Nature Portfolio |
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Abstract | Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolog, regulates the ER export of proinsulin via its recruitment to ER exit sites (ERES). Under high-glucose conditions, Surf4 expression was upregulated, and Surf4 proteins mainly localized to the ER at a steady state and accumulated in the ERES, along with proinsulin in rat insulinoma INS-1 cells. Surf4-knockdown resulted in proinsulin retention in the ER and decreased the levels of mature insulin in secretory granules, thereby significantly reducing insulin secretion. Surf4 forms an oligomer and can physically interact with proinsulin and Sec12, essential for COPII vesicle formation. Our findings suggest that Surf4 interacts with proinsulin and delivers it into COPII vesicles for ER export in co-operation with Sec12 and COPII. |
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AbstractList | Abstract Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolog, regulates the ER export of proinsulin via its recruitment to ER exit sites (ERES). Under high-glucose conditions, Surf4 expression was upregulated, and Surf4 proteins mainly localized to the ER at a steady state and accumulated in the ERES, along with proinsulin in rat insulinoma INS-1 cells. Surf4 -knockdown resulted in proinsulin retention in the ER and decreased the levels of mature insulin in secretory granules, thereby significantly reducing insulin secretion. Surf4 forms an oligomer and can physically interact with proinsulin and Sec12, essential for COPII vesicle formation. Our findings suggest that Surf4 interacts with proinsulin and delivers it into COPII vesicles for ER export in co-operation with Sec12 and COPII. Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolog, regulates the ER export of proinsulin via its recruitment to ER exit sites (ERES). Under high-glucose conditions, Surf4 expression was upregulated, and Surf4 proteins mainly localized to the ER at a steady state and accumulated in the ERES, along with proinsulin in rat insulinoma INS-1 cells. Surf4-knockdown resulted in proinsulin retention in the ER and decreased the levels of mature insulin in secretory granules, thereby significantly reducing insulin secretion. Surf4 forms an oligomer and can physically interact with proinsulin and Sec12, essential for COPII vesicle formation. Our findings suggest that Surf4 interacts with proinsulin and delivers it into COPII vesicles for ER export in co-operation with Sec12 and COPII. Surf4 is an ER cargo receptor for proinsulin, facilitating proinsulin export out of the ERES in a cellular model of pancreatic β-cells, with its expression dependent on glucose concentration and Surf4 knockdown impairing insulin secretion. Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolog, regulates the ER export of proinsulin via its recruitment to ER exit sites (ERES). Under high-glucose conditions, Surf4 expression was upregulated, and Surf4 proteins mainly localized to the ER at a steady state and accumulated in the ERES, along with proinsulin in rat insulinoma INS-1 cells. Surf4-knockdown resulted in proinsulin retention in the ER and decreased the levels of mature insulin in secretory granules, thereby significantly reducing insulin secretion. Surf4 forms an oligomer and can physically interact with proinsulin and Sec12, essential for COPII vesicle formation. Our findings suggest that Surf4 interacts with proinsulin and delivers it into COPII vesicles for ER export in co-operation with Sec12 and COPII.Surf4 is an ER cargo receptor for proinsulin, facilitating proinsulin export out of the ERES in a cellular model of pancreatic β-cells, with its expression dependent on glucose concentration and Surf4 knockdown impairing insulin secretion. Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolog, regulates the ER export of proinsulin via its recruitment to ER exit sites (ERES). Under high-glucose conditions, Surf4 expression was upregulated, and Surf4 proteins mainly localized to the ER at a steady state and accumulated in the ERES, along with proinsulin in rat insulinoma INS-1 cells. Surf4 -knockdown resulted in proinsulin retention in the ER and decreased the levels of mature insulin in secretory granules, thereby significantly reducing insulin secretion. Surf4 forms an oligomer and can physically interact with proinsulin and Sec12, essential for COPII vesicle formation. Our findings suggest that Surf4 interacts with proinsulin and delivers it into COPII vesicles for ER export in co-operation with Sec12 and COPII. Surf4 is an ER cargo receptor for proinsulin, facilitating proinsulin export out of the ERES in a cellular model of pancreatic β-cells, with its expression dependent on glucose concentration and Surf4 knockdown impairing insulin secretion. |
ArticleNumber | 458 |
Author | Maeda, Miharu Saito, Kota Saegusa, Keiko Izumi, Tetsuro Matsunaga, Kohichi Sato, Ken |
Author_xml | – sequence: 1 givenname: Keiko surname: Saegusa fullname: Saegusa, Keiko organization: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, 371-8512, Japan – sequence: 2 givenname: Kohichi surname: Matsunaga fullname: Matsunaga, Kohichi organization: Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, 371-8512, Japan – sequence: 3 givenname: Miharu surname: Maeda fullname: Maeda, Miharu organization: Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, Akita, 010-8543, Japan – sequence: 4 givenname: Kota orcidid: 0000-0003-2478-2687 surname: Saito fullname: Saito, Kota organization: Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, Akita, 010-8543, Japan – sequence: 5 givenname: Tetsuro orcidid: 0000-0002-0974-7384 surname: Izumi fullname: Izumi, Tetsuro organization: Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, 371-8512, Japan – sequence: 6 givenname: Ken orcidid: 0000-0002-1034-5091 surname: Sato fullname: Sato, Ken email: sato-ken@gunma-u.ac.jp, sato-ken@gunma-u.ac.jp organization: Gunma University, Initiative for Advanced Research (GIAR), Gunma, 371-8512, Japan. sato-ken@gunma-u.ac.jp |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35562580$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1021_acs_jproteome_3c00259 crossref_primary_10_3389_fendo_2023_1155779 crossref_primary_10_1002_pro_4949 crossref_primary_10_1091_mbc_E23_03_0090 crossref_primary_10_1042_BST20220713 crossref_primary_10_1038_s41598_024_60687_2 crossref_primary_10_1007_s12035_023_03687_z crossref_primary_10_1016_j_molmet_2023_101845 crossref_primary_10_1172_JCI163838 crossref_primary_10_1161_ATVBAHA_123_318980 crossref_primary_10_1093_jmcb_mjac063 crossref_primary_10_1016_j_molmet_2023_101847 |
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Snippet | Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the... Abstract Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been... Surf4 is an ER cargo receptor for proinsulin, facilitating proinsulin export out of the ERES in a cellular model of pancreatic β-cells, with its expression... |
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SubjectTerms | Beta cells Biology Blood glucose Endoplasmic reticulum Exocytosis Glucose Insulin Insulin secretion Insulinoma Pancreas Secretion Secretory vesicles |
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Title | Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells |
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