Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

• Published in: BMC pediatrics Vol. 21; no. 1; pp. 317 - 8
• Main Authors: Guo, Xuangjie, Xu, Yiping, Luo, Wei, Fang, Rongli, Cai, Li, Wang, Ping, Zhang, Yuxia, Wen, Zhe, Xu, Yanhui
• Format: Journal Article
• Language: English
• Published: England BioMed Central 16.07.2021; BMC
• Subjects: Animals; Animals, Newborn; Apoptosis; Bile ducts; Biliary atresia; Biopsy; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cell death; Disease; Disease Models, Animal; Enzymes; Flow cytometry; Humans; IFN-γ; Infant; Interferon-gamma - immunology; Liver; Lymphocytes; Medical prognosis; Mice; Mice, Inbred BALB C; Newborn babies; Pathogenesis; PD-1; Pediatrics; Programmed Cell Death 1 Receptor; Rotavirus; Statistical analysis; Surgery; Viruses; PD-1; Biliary atresia; IFN-γ

Biliary atresia (BA) is a severe cholangiopathy possibly resulting from virus-induced and immune-mediated injury of the biliary system. IFN-γ, secreted from CD4 Th1 cells and CD8 cytotoxic T cells, is a major mediator of liver pathology. Programmed death protein-1 (PD-1) signaling suppresses T cell...