Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies - Le, Ngoc Phuong Lan; Bowden, Thomas A.; Struwe, Weston B.; Crispin, Max (Biochimica et biophysica acta, 2016)
Keywords: antibodies; Antibody; autoimmunity; binding properties; blood serum; Effector function; engineering; Glycan; Glycosylation; Humans; Immunoglobulin Fc Fragments - genetics; Immunoglobulin Fc Fragments - metabolism; Immunoglobulin Fc Fragments - therapeutic use; immunoglobulin G; Immunoglobulin G - genetics; Immunoglobulin G - metabolism; Immunoglobulin G - therapeutic use; medicine; neoplasms; polysaccharides; Polysaccharides - genetics; Polysaccharides - metabolism; Protein Engineering - methods; receptors; Structure; Therapeutic antibodies; Glycosylation; Structure; Therapeutic antibodies; Antibody; Effector function; Glycan