Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

• Published in: American journal of respiratory and critical care medicine Vol. 199; no. 9; pp. 1127 - 1138
• Main Authors: O’Dwyer, David N., Ashley, Shanna L., Gurczynski, Stephen J., Xia, Meng, Wilke, Carol, Falkowski, Nicole R., Norman, Katy C., Arnold, Kelly B., Huffnagle, Gary B., Salisbury, Margaret L., Han, MeiLan K., Flaherty, Kevin R., White, Eric S., Martinez, Fernando J., Erb-Downward, John R., Murray, Susan, Moore, Bethany B., Dickson, Robert P.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.05.2019
• Subjects: Aged; Animals; Bronchoalveolar Lavage Fluid - microbiology; Cytokines; Deoxyribonucleic acid; Disease Models, Animal; Disease Progression; DNA; Female; Flow Cytometry; Gene expression; Germ-Free Life; Human subjects; Humans; Hypotheses; Idiopathic Pulmonary Fibrosis - microbiology; Idiopathic Pulmonary Fibrosis - pathology; Inflammation; Inflammation - microbiology; Lung - microbiology; Male; Mice; Mice, Inbred C57BL; Microbiota; Microbiota - genetics; Microbiota - physiology; Middle Aged; Mortality; Original; Pathogenesis; Principal components analysis; Pulmonary Alveoli - microbiology; Pulmonary Alveoli - pathology; Pulmonary fibrosis; RNA, Ribosomal, 16S - genetics; Software; bleomycin; germ free; lung microbiota; idiopathic pulmonary fibrosis; inflammation
• ISSN: 1073-449X; 1535-4970; 1535-4970
• DOI: 10.1164/rccm.201809-1650OC

Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent observational studies have reported associations between lung dysbiosis, mortality, and altered host defense gene expression, supporting a r...