Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation - Goode, Kourtney M.; Petrov, Dino P.; Vickman, Renee E.; Crist, Scott A.; Pascuzzi, Pete E.; Ratliff, Tim L.; Davisson, V. Jo; Hazbun, Tony R. (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Adenosine Triphosphatases - antagonists & inhibitors; adenosinetriphosphatase; Allosteric Regulation; Allostery; Benzhydryl Compounds - pharmacology; Binding Sites; bisphenol A; BRCA1 Protein - analysis; C-terminal domain; Cell Line, Tumor; Down-Regulation; heat shock response; HSP90 Heat-Shock Proteins - antagonists & inhibitors; HSP90 Heat-Shock Proteins - chemistry; Hsp90 inhibitor; Humans; In silico modeling; Models, Molecular; molecular models; neoplasm cells; oligomerization; Phenols - pharmacology; Prostate cancer therapeutic; Protein Domains; Protein Multimerization; Small molecule probes; tumor suppressor proteins; C-terminal domain; Allostery; Hsp90 inhibitor; Prostate cancer therapeutic; Small molecule probes; In silico modeling