Noncanonical NF-κB Pathway Controls the Production of Type I Interferons in Antiviral Innate Immunity

• Published in: Immunity (Cambridge, Mass.) Vol. 40; no. 3; pp. 342 - 354
• Main Authors: Jin, Jin, Hu, Hongbo, Li, Haiyan S., Yu, Jiayi, Xiao, Yichuan, Brittain, George C., Zou, Qiang, Cheng, Xuhong, Mallette, Frédérick A., Watowich, Stephanie S., Sun, Shao-Cong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.03.2014
• Subjects: Animals; Cell Differentiation - drug effects; Cell Differentiation - immunology; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - metabolism; Enzyme Activation; Female; Gene Expression Regulation - drug effects; Hematopoietic Cell Growth Factors - pharmacology; Histone Demethylases - metabolism; Histones - metabolism; Immunity, Innate - drug effects; Interferon Type I - biosynthesis; Interferon-beta - genetics; Interferon-beta - metabolism; Ligands; Mice; NF-kappa B - metabolism; NF-kappaB-Inducing Kinase; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases - metabolism; Toll-Like Receptors - metabolism; Transcription Factor RelA - metabolism; Virus Diseases - genetics; Virus Diseases - immunology; Virus Diseases - metabolism

Production of type I interferons (IFN-I) is a crucial innate immune mechanism against viral infections. IFN-I induction is subject to negative regulation by both viral and cellular factors, but the underlying mechanism remains unclear. We report that the noncanonical NF-κB pathway was stimulated alo...