Influence of changed blood pH on anionic sites in the labyrinth
Using polyethyleneimine as a cationic probe, changes in the anionic sites of the labyrinthine basal laminae occurred during acidosis and alkalosis. Hartley-strain guinea pigs (200-300 g) with normal Preyer's reflex were injected i.v. with 0.5% polyethyleneimine (PEI, mol. wt 1800) solution adju...
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Published in | Acta oto-laryngologica Vol. 115; no. 6; p. 747 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
1995
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Subjects | |
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Abstract | Using polyethyleneimine as a cationic probe, changes in the anionic sites of the labyrinthine basal laminae occurred during acidosis and alkalosis. Hartley-strain guinea pigs (200-300 g) with normal Preyer's reflex were injected i.v. with 0.5% polyethyleneimine (PEI, mol. wt 1800) solution adjusted to pH 7.3 with HCI via an axillary vein. The animals were divided into three groups: control, acidosis, and alkalosis. Acidosis was produced by inducing hypoxia, and alkalosis by injecting 7% NaHCO3. In controls, anionic sites were demonstrated on the basal laminae in the labyrinth. During both acidosis and alkalosis, a decreased number of anionic sites were observed on the basal laminae of the capillary walls in both stria vascularis and subepithelial layer of the vestibular sensory epithelium. However, an increase in anionic sites was observed on the basal lamina in Reissner's membrane during both acidosis and alkalosis. |
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AbstractList | Using polyethyleneimine as a cationic probe, changes in the anionic sites of the labyrinthine basal laminae occurred during acidosis and alkalosis. Hartley-strain guinea pigs (200-300 g) with normal Preyer's reflex were injected i.v. with 0.5% polyethyleneimine (PEI, mol. wt 1800) solution adjusted to pH 7.3 with HCI via an axillary vein. The animals were divided into three groups: control, acidosis, and alkalosis. Acidosis was produced by inducing hypoxia, and alkalosis by injecting 7% NaHCO3. In controls, anionic sites were demonstrated on the basal laminae in the labyrinth. During both acidosis and alkalosis, a decreased number of anionic sites were observed on the basal laminae of the capillary walls in both stria vascularis and subepithelial layer of the vestibular sensory epithelium. However, an increase in anionic sites was observed on the basal lamina in Reissner's membrane during both acidosis and alkalosis. |
Author | Kitamura, K Nomura, Y Suzuki, M |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8749195$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Acidosis - chemically induced Alkalosis - chemically induced Animals Anions - metabolism Basement Membrane - blood supply Basement Membrane - metabolism Basement Membrane - ultrastructure Ear, Inner - blood supply Ear, Inner - metabolism Guinea Pigs Hydrogen-Ion Concentration Indicators and Reagents - pharmacokinetics Polyethyleneimine - pharmacokinetics |
Title | Influence of changed blood pH on anionic sites in the labyrinth |
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