Trypanosoma cruzi infection results in an increase in intracellular cholesterol
Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin America and among immigrant populations in non-endemic areas. T. cruzi has a high affinity for host lipoproteins and uses the low density lipoprotein receptor (LDLr) for invasion. Herein, we report that T. cruzi i...
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| Published in | Microbes and infection Vol. 16; no. 4; pp. 337 - 344 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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01.04.2014
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| Abstract | Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin America and among immigrant populations in non-endemic areas. T. cruzi has a high affinity for host lipoproteins and uses the low density lipoprotein receptor (LDLr) for invasion. Herein, we report that T. cruzi infection is associated with an accumulation of LDL and cholesterol in tissues in both acute and chronic murine Chagas disease. Similar findings were observed in tissue samples from a human case of Chagasic cardiomyopathy. T. cruzi infection of cultured cells displayed increased invasion with increasing cholesterol levels in the medium. Studies of infected host cells demonstrated alterations in their cholesterol regulation. T. cruzi invasion/infection via LDLr appears to be involved in changes in intracellular cholesterol homeostasis. The observed changes in intracellular lipids and associated oxidative stress due to these elevated lipids may contribute to the development of Chagasic cardiomyopathy. |
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| AbstractList | Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin America and among immigrant populations in non-endemic areas. T. cruzi has a high affinity for host lipoproteins and uses the low density lipoprotein receptor (LDLr) for invasion. Herein, we report that T. cruzi infection is associated with an accumulation of LDL and cholesterol in tissues in both acute and chronic murine Chagas disease. Similar findings were observed in tissue samples from a human case of Chagasic cardiomyopathy. T. cruzi infection of cultured cells displayed increased invasion with increasing cholesterol levels in the medium. Studies of infected host cells demonstrated alterations in their cholesterol regulation. T. cruzi invasion/infection via LDLr appears to be involved in changes in intracellular cholesterol homeostasis. The observed changes in intracellular lipids and associated oxidative stress due to these elevated lipids may contribute to the development of Chagasic cardiomyopathy. Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin America and among immigrant populations in non-endemic areas. T. cruzi has a high affinity for host lipoproteins and uses the low density lipoprotein receptor (LDLr) for invasion. Herein, we report that T. cruzi infection is associated with an accumulation of LDL and cholesterol in tissues in both acute and chronic murine Chagas disease. Similar findings were observed in tissue samples from a human case of Chagasic cardiomyopathy. T. cruzi infection of cultured cells displayed increased invasion with increasing cholesterol levels in the medium. Studies of infected host cells demonstrated alterations in their cholesterol regulation. T. cruzi invasion/infection via LDLr appears to be involved in changes in intracellular cholesterol homeostasis. The observed changes in intracellular lipids and associated oxidative stress due to these elevated lipids may contribute to the development of Chagasic cardiomyopathy. |
| Author | Johndrow, Christopher Tanowitz, Herbert Weiss, Louis M. Nelson, Randin Nagajyothi, Fnu |
| AuthorAffiliation | 1 Department of Pathology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York 2 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York |
| AuthorAffiliation_xml | – name: 1 Department of Pathology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York – name: 2 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York |
| Author_xml | – sequence: 1 givenname: Christopher surname: Johndrow fullname: Johndrow, Christopher organization: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA – sequence: 2 givenname: Randin orcidid: 0000-0002-0455-1235 surname: Nelson fullname: Nelson, Randin organization: Department of Pathology, Montefiore Medical Center, Bronx, NY, USA – sequence: 3 givenname: Herbert surname: Tanowitz fullname: Tanowitz, Herbert organization: Department of Pathology, Montefiore Medical Center, Bronx, NY, USA – sequence: 4 givenname: Louis M. surname: Weiss fullname: Weiss, Louis M. organization: Department of Pathology, Montefiore Medical Center, Bronx, NY, USA – sequence: 5 givenname: Fnu surname: Nagajyothi fullname: Nagajyothi, Fnu email: Fnu.nagajyothi@einstein.yu.edu organization: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24486184$$D View this record in MEDLINE/PubMed |
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| Keywords | Chagas disease LDL Pathogenesis Cholesterol Invasion Trypanosoma cruzi |
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| Snippet | Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin America and among immigrant populations in non-endemic areas. T. cruzi... Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin America and among immigrant populations in non-endemic areas. T. cruzi... |
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| SubjectTerms | Animals Chagas disease Chagas Disease - parasitology Chagas Disease - pathology Cholesterol Cholesterol - analysis Cytoplasm - chemistry Disease Models, Animal Humans Invasion LDL Lipoproteins, LDL - analysis Male Mice Oxidative Stress Pathogenesis Trypanosoma cruzi Trypanosoma cruzi - physiology |
| Title | Trypanosoma cruzi infection results in an increase in intracellular cholesterol |
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