The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized clinical trial

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 45; no. 13; pp. 2189 - 2197
• Main Authors: Mylonas, Dimitrios, Baran, Bengi, Demanuele, Charmaine, Cox, Roy, Vuper, Tessa C, Seicol, Benjamin J, Fowler, Rachel A, Correll, David, Parr, Elaine, Callahan, Cameron E, Morgan, Alexandra, Henderson, David, Vangel, Mark, Stickgold, Robert, Manoach, Dara S
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2020; Springer International Publishing
• Subjects: Activity patterns; Animal behavior; Animal memory; Clinical trials; Cross-Over Studies; Double-Blind Method; Electroencephalography; Eszopiclone; Frequency dependence; Humans; Memory Consolidation; Mental disorders; NREM sleep; Oscillations; REM sleep; Schizophrenia; Schizophrenia - drug therapy; Sleep; Sleep Stages; Thalamus

Sleep spindles, defining oscillations of stage 2 non-rapid eye movement sleep (N2), mediate memory consolidation. Schizophrenia is characterized by reduced spindle activity that correlates with impaired sleep-dependent memory consolidation. In a small, randomized, placebo-controlled pilot study of s...